Stem cells and their local microenvironment, or niche, communicate through mechanical
cues to regulate cell fate and cell behaviour and to guide developmental processes. During …

The adult heart is a vital and highly specialized organ of the human body, with limited
capability of self-repair and regeneration in case of injury or disease. Engineering …

There has been considerable progress in engineering cardiac scaffolds for the treatment of
myocardial infarction (MI). However, it is still challenging to replicate the structural specificity …

Three-dimensional (3D) bioprinting of hydrogel-based constructs at adequate consistency
and reproducibility can be obtained through a compromise between the hydrogel's inherent …

Pluripotent stem-cell-derived cardiomyocytes (PSC-CMs) provide an unprecedented
opportunity to study human heart development and disease, but they are functionally and …

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) grown in
engineered heart tissue (EHT) can be used for drug screening, disease modeling, and heart …

We developed a heart-on-a-chip platform that integrates highly flexible, vertical, 3D
micropillar electrodes for electrophysiological recording and elastic microwires for the …

Introduction: Biomaterials have provided a wide range of exciting opportunities in tissue
engineering and regenerative medicine. Gelatin, a collagen-derived natural biopolymer, has …

The cross-talk between stem cells and their microenvironment has been shown to have a
direct impact on stem cells' decisions about proliferation, growth, migration, and …

Neuroblastoma (NB) is the most common extracranial tumor in children resulting in
substantial morbidity and mortality. A deeper understanding of the NB tumor …