Artificial intelligence for quantitative modeling in drug discovery and development: An innovation and quality consortium perspective on use cases and best practices
Recent breakthroughs in artificial intelligence (AI) and machine learning (ML) have ushered
in a new era of possibilities across various scientific domains. One area where these …
in a new era of possibilities across various scientific domains. One area where these …
[HTML][HTML] Electroencephalogram-based pharmacodynamic measures: a review
M Bewernitz, H Derendorf - International journal of clinical …, 2012 - ncbi.nlm.nih.gov
Pharmacokinetics and pharmacodynamics can provide a useful modeling framework for
predicting drug activity and can serve as a basis for dose optimization. Determining a …
predicting drug activity and can serve as a basis for dose optimization. Determining a …
Effectiveness, safety, and pharmacokinetic and pharmacodynamic characteristics of microemulsion propofol in patients undergoing elective surgery under total …
Background The aims of this study were to investigate the effectiveness, safety,
pharmacokinetics, and pharmacodynamics of microemulsion propofol, Aquafol™(Daewon …
pharmacokinetics, and pharmacodynamics of microemulsion propofol, Aquafol™(Daewon …
[PDF][PDF] Propofol and remifentanil differentially modulate frontal electroencephalographic activity
Background: The purpose of this study was to evaluate a new, physiologically inspired
method for the analysis of the electroencephalogram during propofol–remifentanil …
method for the analysis of the electroencephalogram during propofol–remifentanil …
Machine learning methods applied to pharmacokinetic modelling of remifentanil in healthy volunteers: a multi-method comparison
MR Poynton, BM Choi, YM Kim… - Journal of …, 2009 - journals.sagepub.com
This study compared the blood concentrations of remifentanil obtained in a previous clinical
investigation with the predicted remifentanil concentrations produced by different …
investigation with the predicted remifentanil concentrations produced by different …
Modeling the effect of propofol and remifentanil combinations for sedation-analgesia in endoscopic procedures using an Adaptive Neuro Fuzzy Inference System …
PL Gambús, EW Jensen, M Jospin, X Borrat… - Anesthesia & …, 2011 - journals.lww.com
BACKGROUND: The increasing demand for anesthetic procedures in the gastrointestinal
endoscopy area has not been followed by a similar increase in the methods to provide and …
endoscopy area has not been followed by a similar increase in the methods to provide and …
Artificial intelligence and its applications in drug discovery, formulation development, and healthcare
D Banerjee, D Rajput, S Banerjee… - … Aided Pharmaceutics and …, 2022 - Springer
Artificial intelligence (AI) is a vast multidisciplinary field which equip machines with cognitive
powers like ability to perceive reason, learn, abstract, and act. Machine learning (ML) and …
powers like ability to perceive reason, learn, abstract, and act. Machine learning (ML) and …
[PDF][PDF] Application of counter-propagation artificial neural networks in prediction of topiramate concentration in patients with epilepsy
M Jovanovic, D Sokić, I Grabnar… - … of pharmacy & …, 2015 - frontierspartnerships.org
Purpose: The application of artificial neural networks in the pharmaceutical sciences is
broad, ranging from drug discovery to clinical pharmacy. In this study, we explored the …
broad, ranging from drug discovery to clinical pharmacy. In this study, we explored the …
Pharmacokinetics and pharmacodynamics of a new reformulated microemulsion and the long‐chain triglyceride emulsion of propofol in beagle dogs
SH Lee, JL Ghim, MH Song, HG Choi… - British Journal of …, 2009 - Wiley Online Library
Background and purpose: Microemulsion propofol was developed to eliminate lipid solvent‐
related adverse events of long‐chain triglyceride emulsion (LCT) propofol. We compared …
related adverse events of long‐chain triglyceride emulsion (LCT) propofol. We compared …
Dexamethasone-releasing cochlear implant coatings: application of artificial neural networks for modelling of formulation parameters and drug release profile
Objectives Over the past few decades, mathematical modelling and simulation of drug
delivery systems has been steadily gained interest as a focus for academic and industrial …
delivery systems has been steadily gained interest as a focus for academic and industrial …