Artificial intelligence for quantitative modeling in drug discovery and development: An innovation and quality consortium perspective on use cases and best practices

N Terranova, D Renard, MH Shahin… - Clinical …, 2024 - Wiley Online Library
Recent breakthroughs in artificial intelligence (AI) and machine learning (ML) have ushered
in a new era of possibilities across various scientific domains. One area where these …

[HTML][HTML] Electroencephalogram-based pharmacodynamic measures: a review

M Bewernitz, H Derendorf - International journal of clinical …, 2012 - ncbi.nlm.nih.gov
Pharmacokinetics and pharmacodynamics can provide a useful modeling framework for
predicting drug activity and can serve as a basis for dose optimization. Determining a …

Effectiveness, safety, and pharmacokinetic and pharmacodynamic characteristics of microemulsion propofol in patients undergoing elective surgery under total …

JA Jung, BM Choi, SH Cho, SM Choe… - British journal of …, 2010 - academic.oup.com
Background The aims of this study were to investigate the effectiveness, safety,
pharmacokinetics, and pharmacodynamics of microemulsion propofol, Aquafol™(Daewon …

[PDF][PDF] Propofol and remifentanil differentially modulate frontal electroencephalographic activity

DTJ Liley, NC Sinclair, T Lip**, B Heyse… - …, 2010 - academia.edu
Background: The purpose of this study was to evaluate a new, physiologically inspired
method for the analysis of the electroencephalogram during propofol–remifentanil …

Machine learning methods applied to pharmacokinetic modelling of remifentanil in healthy volunteers: a multi-method comparison

MR Poynton, BM Choi, YM Kim… - Journal of …, 2009 - journals.sagepub.com
This study compared the blood concentrations of remifentanil obtained in a previous clinical
investigation with the predicted remifentanil concentrations produced by different …

Modeling the effect of propofol and remifentanil combinations for sedation-analgesia in endoscopic procedures using an Adaptive Neuro Fuzzy Inference System …

PL Gambús, EW Jensen, M Jospin, X Borrat… - Anesthesia & …, 2011 - journals.lww.com
BACKGROUND: The increasing demand for anesthetic procedures in the gastrointestinal
endoscopy area has not been followed by a similar increase in the methods to provide and …

Artificial intelligence and its applications in drug discovery, formulation development, and healthcare

D Banerjee, D Rajput, S Banerjee… - … Aided Pharmaceutics and …, 2022 - Springer
Artificial intelligence (AI) is a vast multidisciplinary field which equip machines with cognitive
powers like ability to perceive reason, learn, abstract, and act. Machine learning (ML) and …

[PDF][PDF] Application of counter-propagation artificial neural networks in prediction of topiramate concentration in patients with epilepsy

M Jovanovic, D Sokić, I Grabnar… - … of pharmacy & …, 2015 - frontierspartnerships.org
Purpose: The application of artificial neural networks in the pharmaceutical sciences is
broad, ranging from drug discovery to clinical pharmacy. In this study, we explored the …

Pharmacokinetics and pharmacodynamics of a new reformulated microemulsion and the long‐chain triglyceride emulsion of propofol in beagle dogs

SH Lee, JL Ghim, MH Song, HG Choi… - British Journal of …, 2009 - Wiley Online Library
Background and purpose: Microemulsion propofol was developed to eliminate lipid solvent‐
related adverse events of long‐chain triglyceride emulsion (LCT) propofol. We compared …

Dexamethasone-releasing cochlear implant coatings: application of artificial neural networks for modelling of formulation parameters and drug release profile

P Nemati, M Imani, F Farahmandghavi… - Journal of Pharmacy …, 2013 - academic.oup.com
Objectives Over the past few decades, mathematical modelling and simulation of drug
delivery systems has been steadily gained interest as a focus for academic and industrial …