Transplantation is the only curative treatment for patients with kidney failure but it poses
unique immunological challenges that must be overcome to prevent allograft rejection and …

The actin cytoskeleton is composed of dynamic filament networks that build adaptable local
architectures to sustain nearly all cellular activities in response to a myriad of stimuli …

Memory T cells that are specific for alloantigen can arise from a variety of stimuli, ranging
from direct allogeneic sensitization from prior transplantation, blood transfusion, or …

Bovine tuberculosis is a chronic consumptive zoonosis, causing significant economic losses
and critical public health risks. Coronin-1A is a host cytoskeleton-associated protein that is …

Maintenance of cell population size is fundamental to the proper functioning of multicellular
organisms. Here, we describe a cell-intrinsic cell density–sensing pathway that enabled T …

The control of T cell survival is crucial for defense against infectious pathogens or emerging
cancers. Although the survival of peripheral naïve T cells has been proposed to be …

Introduction Recent work identified members of the evolutionarily conserved coronin protein
family as key regulators of cell population size. This work originated~ 25 years ago through …

Graft-versus-host disease (GVHD) is a serious inflammatory illness that often occurs as a
secondary complication of bone marrow transplantation. Current therapies have limited …

Lifelong systemic immunosuppression remains the biggest challenge in vascularized
composite allotransplantation (VCA) due to the adverse effects it causes. Since VCA is a life …

Background: The incidence of noncommunicable diseases (NCDs) has been rapidly
ramped up worldwide. Hence, there is an urgent need to non-invasively detect NCDs …