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Glomerular nephrotoxicity of aminoglycosides
Aminoglycoside antibiotics are the most commonly used antibiotics worldwide in the
treatment of Gram-negative bacterial infections. However, aminoglycosides induce …
treatment of Gram-negative bacterial infections. However, aminoglycosides induce …
The calcium-sensing receptor: a molecular perspective
AL Magno, BK Ward, T Ratajczak - Endocrine reviews, 2011 - academic.oup.com
Compelling evidence of a cell surface receptor sensitive to extracellular calcium was
observed as early as the 1980s and was finally realized in 1993 when the calcium-sensing …
observed as early as the 1980s and was finally realized in 1993 when the calcium-sensing …
Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells
M Alam, JP Kirton, FL Wilkinson, E Towers… - Cardiovascular …, 2009 - academic.oup.com
Aims Vascular calcification (VC) is highly correlated with increased morbidity and mortality in
advanced chronic kidney disease (CKD) patients. Allosteric modulation of the calcium …
advanced chronic kidney disease (CKD) patients. Allosteric modulation of the calcium …
Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor
The calcium-sensing receptor (CaSR) is a G protein-coupled receptor whose function can
be allosterically modulated in a positive or negative manner by calcimimetics or calcilytics …
be allosterically modulated in a positive or negative manner by calcimimetics or calcilytics …
Magnesium and outcomes in patients with chronic kidney disease: focus on vascular calcification, atherosclerosis and survival
ZA Massy, TB Drüeke - Clinical kidney journal, 2012 - academic.oup.com
Patients with chronic kidney disease (CKD) have a high prevalence of vascular calcification,
and cardiovascular disease is the leading cause of death in this population. However, the …
and cardiovascular disease is the leading cause of death in this population. However, the …
Enhanced Ca2+-Sensing Receptor Function in Idiopathic Pulmonary Arterial Hypertension
A Yamamura, Q Guo, H Yamamura… - Circulation …, 2012 - ahajournals.org
Rationale: A rise in cytosolic Ca2+ concentration ([Ca2+] cyt) in pulmonary arterial smooth
muscle cells (PASMC) is an important stimulus for pulmonary vasoconstriction and vascular …
muscle cells (PASMC) is an important stimulus for pulmonary vasoconstriction and vascular …
Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast …
The calcium-sensing receptor (CaR) is a G-protein-coupled receptor that signals in
response to extracellular calcium and regulates parathyroid hormone secretion. The CaR is …
response to extracellular calcium and regulates parathyroid hormone secretion. The CaR is …
Extracellular calcium-sensing receptor is functionally expressed in human artery
G Molostvov, S James, S Fletcher… - American Journal …, 2007 - journals.physiology.org
Accelerated medial calcification is a major cause of premature cardiovascular mortality in
patients with chronic kidney disease (CKD). Evidence suggests that extracellular …
patients with chronic kidney disease (CKD). Evidence suggests that extracellular …
Vascular calcification in chronic renal failure: what have we learned from animal studies?
Accelerated atherosclerotic plaque calcification and extensive medial calcifications are
common and highly detrimental complications of chronic kidney disease. Valid murine …
common and highly detrimental complications of chronic kidney disease. Valid murine …
The calcimimetic R-568 retards uremia-enhanced vascular calcification and atherosclerosis in apolipoprotein E deficient (apoE−/−) mice
OBJECTIVE: Secondary hyperparathyroidism of chronic kidney disease promotes vascular
calcification. Calcimimetics reduce serum parathyroid hormone, calcium (Ca), and …
calcification. Calcimimetics reduce serum parathyroid hormone, calcium (Ca), and …