Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling
molecules that control various cellular functions. Nrf2 governs the gene expression of …

The mitochondrial transcription factor A, or TFAM, is a mitochondrial DNA (mt DNA)‐binding
protein essential for genome maintenance. TFAM functions in determining the abundance of …

Mutations in mitochondrial DNA (mtDNA) play critical roles in many human diseases. In vivo
visualization of cells bearing mtDNA mutations is important for resolving the complexity of …

DddA-derived cytosine base editors (DdCBEs), composed of the split interbacterial toxin
DddAtox, transcription activator-like effector (TALE), and uracil glycosylase inhibitor (UGI) …

Mutations in the mitochondrial DNA (mtDNA) are responsible for several metabolic
disorders, commonly involving muscle and the central nervous system. Because of the …

Inherited disorders of oxidative phosphorylation cause the clinically and genetically
heterogeneous diseases known as mitochondrial energy generation disorders, or …

Genomic databases of allele frequency are extremely helpful for evaluating clinical variants
of unknown significance; however, until now, databases such as the Genome Aggregation …

Intellectual disability (ID) can be caused by non-genetic and genetic factors, the latter being
responsible for more than 1700 ID-related disorders. The broad ID phenotypic and genetic …

Mitochondrial dysfunction is widely implicated in various human diseases, through
mechanisms that go beyond mitochondria's well-established role in energy generation …

Mitochondrial dysfunction underlies the etiology of a broad spectrum of diseases including
heart disease, cancer, neurodegenerative diseases, and the general aging process …