Prefrontal cortex development in health and disease: lessons from rodents and humans
M Chini, IL Hanganu-Opatz - Trends in neurosciences, 2021 - cell.com
The role of the prefrontal cortex (PFC) takes center stage among unanswered questions in
modern neuroscience. The PFC has a Janus-faced nature: it enables sophisticated cognitive …
modern neuroscience. The PFC has a Janus-faced nature: it enables sophisticated cognitive …
Aberrant maturation and connectivity of prefrontal cortex in schizophrenia—contribution of NMDA receptor development and hypofunction
The neurobiology of schizophrenia involves multiple facets of pathophysiology, ranging from
its genetic basis over changes in neurochemistry and neurophysiology, to the systemic level …
its genetic basis over changes in neurochemistry and neurophysiology, to the systemic level …
Increased fMRI connectivity upon chemogenetic inhibition of the mouse prefrontal cortex
While shaped and constrained by axonal connections, fMRI-based functional connectivity
reorganizes in response to varying interareal input or pathological perturbations. However …
reorganizes in response to varying interareal input or pathological perturbations. However …
Thalamocortical organoids enable in vitro modeling of 22q11. 2 microdeletion associated with neuropsychiatric disorders
Thalamic dysfunction has been implicated in multiple psychiatric disorders. We sought to
study the mechanisms by which abnormalities emerge in the context of the 22q11. 2 …
study the mechanisms by which abnormalities emerge in the context of the 22q11. 2 …
Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia
Abstract 16p11. 2 and 22q11. 2 Copy Number Variants (CNVs) confer high risk for Autism
Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder …
Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder …
Dissecting autism and schizophrenia through neuroimaging genomics
Neuroimaging genomic studies of autism spectrum disorder and schizophrenia have mainly
adopted a 'top-down'approach, beginning with the behavioural diagnosis, and moving down …
adopted a 'top-down'approach, beginning with the behavioural diagnosis, and moving down …
A developmental increase of inhibition promotes the emergence of hippocampal ripples
Sharp wave-ripples (SPW-Rs) are a hippocampal network phenomenon critical for memory
consolidation and planning. SPW-Rs have been extensively studied in the adult brain, yet …
consolidation and planning. SPW-Rs have been extensively studied in the adult brain, yet …
Impaired theta phase coupling underlies frontotemporal dysconnectivity in schizophrenia
Frontotemporal dysconnectivity is a key pathology in schizophrenia. The specific nature of
this dysconnectivity is unknown, but animal models imply dysfunctional theta phase coupling …
this dysconnectivity is unknown, but animal models imply dysfunctional theta phase coupling …
The thalamus in psychosis spectrum disorder
Psychosis spectrum disorder (PSD) affects 1% of the world population and results in a
lifetime of chronic disability, causing devastating personal and economic consequences …
lifetime of chronic disability, causing devastating personal and economic consequences …
Abnormal development and dysconnectivity of distinct thalamic nuclei in patients with 22q11. 2 deletion syndrome experiencing auditory hallucinations
Background Several studies in patients with schizophrenia have demonstrated an abnormal
thalamic volume and thalamocortical connectivity. Specifically, hyperconnectivity with …
thalamic volume and thalamocortical connectivity. Specifically, hyperconnectivity with …