Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis
Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis
and contribute to the development of novel diagnostic and therapeutic strategies to further …
and contribute to the development of novel diagnostic and therapeutic strategies to further …
Inflammation in atherosclerosis
P Libby - Arteriosclerosis, thrombosis, and vascular biology, 2012 - Am Heart Assoc
Experimental work has elucidated molecular and cellular pathways of inflammation that
promote atherosclerosis. Unraveling the roles of cytokines as inflammatory messengers …
promote atherosclerosis. Unraveling the roles of cytokines as inflammatory messengers …
Inflammation and atherosclerosis
Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an
ongoing inflammatory response. Recent advances in basic science have established a …
ongoing inflammatory response. Recent advances in basic science have established a …
Atherosclerosis—an inflammatory disease
R Ross - New England journal of medicine, 1999 - Mass Medical Soc
Atherosclerosis is an inflammatory disease. Because high plasma concentrations of
cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the …
cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the …
Macrophages in the pathogenesis of atherosclerosis
In atherosclerosis, the accumulation of apolipoprotein B-lipoproteins in the matrix beneath
the endothelial cell layer of blood vessels leads to the recruitment of monocytes, the cells of …
the endothelial cell layer of blood vessels leads to the recruitment of monocytes, the cells of …
Atherosclerosis.
P Libby, JE Buring, L Badimon… - Nature reviews …, 2019 - europepmc.org
Atherosclerosis, the formation of fibrofatty lesions in the artery wall, causes much morbidity
and mortality worldwide, including most myocardial infarctions and many strokes, as well as …
and mortality worldwide, including most myocardial infarctions and many strokes, as well as …
Matrix metalloproteinases
H Nagase - Zinc metalloproteases in health and disease, 1996 - taylorfrancis.com
Matrix metalloproteinases (MMPs), also designated matnxms, are a family of related zinc
metalloendopeptidases that function in the turnover of components of the extracellular …
metalloendopeptidases that function in the turnover of components of the extracellular …
Coronary plaque disruption
Coronary atherosclerosis is by far the most frequent cause of ischemic heart disease, and
plaque disruption with superimposed thrombosis is the main cause of the acute coronary …
plaque disruption with superimposed thrombosis is the main cause of the acute coronary …
Molecular regulation of vascular smooth muscle cell differentiation in development and disease
GK Owens, MS Kumar… - Physiological reviews, 2004 - journals.physiology.org
The focus of this review is to provide an overview of the current state of knowledge of
molecular mechanisms/processes that control differentiation of vascular smooth muscle cells …
molecular mechanisms/processes that control differentiation of vascular smooth muscle cells …
Mechanisms of acute coronary syndromes and their implications for therapy
P Libby - New England Journal of Medicine, 2013 - Mass Medical Soc
The notion that heart attacks develop from coronary-artery stenosis is an oversimplification
of a process involving lipid metabolism, inflammation, macrophage activation, collagen …
of a process involving lipid metabolism, inflammation, macrophage activation, collagen …