Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

W Chen, M Schilperoort, Y Cao, J Shi, I Tabas… - Nature Reviews …, 2022 - nature.com
Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis
and contribute to the development of novel diagnostic and therapeutic strategies to further …

Inflammation in atherosclerosis

P Libby - Arteriosclerosis, thrombosis, and vascular biology, 2012 - Am Heart Assoc
Experimental work has elucidated molecular and cellular pathways of inflammation that
promote atherosclerosis. Unraveling the roles of cytokines as inflammatory messengers …

Inflammation and atherosclerosis

P Libby, PM Ridker, A Maseri - Circulation, 2002 - Am Heart Assoc
Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an
ongoing inflammatory response. Recent advances in basic science have established a …

Atherosclerosis—an inflammatory disease

R Ross - New England journal of medicine, 1999 - Mass Medical Soc
Atherosclerosis is an inflammatory disease. Because high plasma concentrations of
cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the …

Macrophages in the pathogenesis of atherosclerosis

KJ Moore, I Tabas - Cell, 2011 - cell.com
In atherosclerosis, the accumulation of apolipoprotein B-lipoproteins in the matrix beneath
the endothelial cell layer of blood vessels leads to the recruitment of monocytes, the cells of …

Atherosclerosis.

P Libby, JE Buring, L Badimon… - Nature reviews …, 2019 - europepmc.org
Atherosclerosis, the formation of fibrofatty lesions in the artery wall, causes much morbidity
and mortality worldwide, including most myocardial infarctions and many strokes, as well as …

Matrix metalloproteinases

H Nagase - Zinc metalloproteases in health and disease, 1996 - taylorfrancis.com
Matrix metalloproteinases (MMPs), also designated matnxms, are a family of related zinc
metalloendopeptidases that function in the turnover of components of the extracellular …

Coronary plaque disruption

E Falk, PK Shah, V Fuster - Circulation, 1995 - Am Heart Assoc
Coronary atherosclerosis is by far the most frequent cause of ischemic heart disease, and
plaque disruption with superimposed thrombosis is the main cause of the acute coronary …

Molecular regulation of vascular smooth muscle cell differentiation in development and disease

GK Owens, MS Kumar… - Physiological reviews, 2004 - journals.physiology.org
The focus of this review is to provide an overview of the current state of knowledge of
molecular mechanisms/processes that control differentiation of vascular smooth muscle cells …

Mechanisms of acute coronary syndromes and their implications for therapy

P Libby - New England Journal of Medicine, 2013 - Mass Medical Soc
The notion that heart attacks develop from coronary-artery stenosis is an oversimplification
of a process involving lipid metabolism, inflammation, macrophage activation, collagen …