Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …

Major recent advances and previous data have led to a plausible model of how key proteins
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …

Albumin, the most abundant plasma protein, is among the most studied of all proteins, being
important from clinical monitoring, physiological, and therapeutic perspectives. This unique …

Since the discovery of SNARE proteins in the late 1980s, SNAREs have been recognized as
key components of protein complexes that drive membrane fusion. Despite considerable …

During an action potential, Ca 2+ entering a presynaptic terminal triggers synaptic vesicle
exocytosis and neurotransmitter release in less than a millisecond. How does Ca 2+ …

▪ Abstract Neurotransmitter release is mediated by exocytosis of synaptic vesicles at the
presynaptic active zone of nerve terminals. To support rapid and repeated rounds of release …

Recombinant v-and t-SNARE proteins reconstituted into separate lipid bilayer vesicles
assemble into SNAREpins—SNARE complexes linking two membranes. This leads to …

The two universally required components of the intracellular membrane fusion machinery,
SNARE and SM (Sec1/Munc18-like) proteins, play complementary roles in fusion. Vesicular …

Genetic and biochemical analyses of the secretory pathway have produced a detailed
picture of the molecular mechanisms involved in selective cargo transport between …

The SNARE hypothesis holds that a transport vesicle chooses its target for fusion when a
soluble NSF attachment protein (SNAP) receptor on the vesicle (V-SNARE) pairs with its …