Cholestasis is a clinical condition resulting from the imapairment of bile flow. This condition
could be caused by defects of the hepatocytes, which are responsible for the complex …

Monogenic intestinal epithelial disorders, also known as congenital diarrheas and
enteropathies (CoDEs), are a group of rare diseases that result from mutations in genes that …

Monogenetic variants are responsible for a range of congenital human diseases. Variants in
genes that are important for intestinal epithelial function cause a group of disorders …

ABSTRACT Background & Aim Clostridioides difficile infection (CDI) is the leading cause of
hospital-acquired diarrhea and pseudomembranous colitis. Two protein toxins, TcdA and …

Microvillus inclusion disease (MVID), caused by loss-of-function mutations in the motor
protein myosin Vb (MYO5B), is a severe infantile disease characterized by diarrhea …

Aquaporins (AQP) are a class of water channel membrane proteins that are widely
expressed in the gut. The biological functions of aquaporins, which regulate the absorption …

Hereditary cholestatic liver disease caused by a class of autosomal gene mutations results
in jaundice, which involves the abnormality of the synthesis, secretion, and other disorders …

Background & Aim Myosin VB (MYO5B) is an essential trafficking protein for membrane
recycling in gastrointestinal epithelial cells. The inactivating mutations of MYO5B cause the …

Functional loss of myosin Vb (MYO5B) induces a variety of deficits in intestinal epithelial cell
function and causes a congenital diarrheal disorder, microvillus inclusion disease (MVID) …

Functional loss of the motor protein myosin Vb (MYO5B) induces various defects in intestinal
epithelial function and causes a congenital diarrheal disorder, namely, microvillus inclusion …