Radioactive transition metals for imaging and therapy

E Boros, AB Packard - Chemical reviews, 2018 - ACS Publications
Nuclear medicine is composed of two complementary areas, imaging and therapy. Positron
emission tomography (PET) and single-photon imaging, including single-photon emission …

Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease

TJ Wadas, EH Wong, GR Weisman… - Chemical …, 2010 - ACS Publications
Molecular imaging is the visualization, characterization, and measurement of biological
processes at the molecular and cellular levels in humans and other living systems …

Hypoxia-specific ultrasensitive detection of tumours and cancer cells in vivo

X Zheng, X Wang, H Mao, W Wu, B Liu… - Nature communications, 2015 - nature.com
Highly sensitive and specific non-invasive molecular imaging methods are particularly
desirable for the early detection of cancers. Here we report a near-infrared optical imaging …

Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical research

CJ Anderson, R Ferdani - Cancer Biotherapy and …, 2009 - liebertpub.com
Summation Copper-64 (T1/2= 12.7 hours; β+, 0.653 MeV [17.8%]; β−, 0.579 MeV [38.4%])
has decay characteristics that allow for positron emission tomography (PET) imaging and …

Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy

JL Tatum - International journal of radiation biology, 2006 - Taylor & Francis
Purpose: The Cancer Imaging Program of the National Cancer Institute convened a
workshop to assess the current status of hypoxia imaging, to assess what is known about the …

PET radiopharmaceuticals for imaging of tumor hypoxia: a review of the evidence

E Lopci, I Grassi, A Chiti, C Nanni… - American journal of …, 2014 - pmc.ncbi.nlm.nih.gov
Hypoxia is a pathological condition arising in living tissues when oxygen supply does not
adequately cover the cellular metabolic demand. Detection of this phenomenon in tumors is …

Copper complexes of bis (thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals

BM Paterson, PS Donnelly - Chemical Society Reviews, 2011 - pubs.rsc.org
The molecules known as bis (thiosemicarbazones) derived from 1, 2-diones can act as
tetradentate ligands for Cu (II), forming stable, neutral complexes. As a family, these …

A novel approach to overcome hypoxic tumor resistance: Cu-ATSM-guided intensity-modulated radiation therapy

KSC Chao, WR Bosch, S Mutic, JS Lewis… - International Journal of …, 2001 - Elsevier
Purpose: Locoregional tumor control for locally advanced cancers with radiation therapy has
been unsatisfactory. This is in part associated with the phenomenon of tumor hypoxia …

Copper chelation chemistry and its role in copper radiopharmaceuticals

TJ Wadas, EH Wong, GR Weisman… - Current …, 2007 - ingentaconnect.com
Molecular imaging is an important scientific discipline that plays a major role in clinical
medicine and pharmaceutical development. While several imaging modalities including X …

In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM

F Dehdashti, MA Mintun, JS Lewis, J Bradley… - European journal of …, 2003 - Springer
Tumor hypoxia is recognized as an important determinant of response to therapy. In this
study we investigated the feasibility of clinical imaging with copper-60 diacetyl-bis (N 4 …