The rise of continuous flow biocatalysis–fundamentals, very recent developments and future perspectives

P De Santis, LE Meyer, S Kara - Reaction Chemistry & Engineering, 2020 - pubs.rsc.org
Biocatalysis community has witnessed a drastic increase in the number of studies for the use
of enzymes in continuously operated flow reactors. This significant interest arose from the …

Continuous‐flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients

B Gutmann, D Cantillo… - Angewandte Chemie …, 2015 - Wiley Online Library
In the past few years, continuous‐flow reactors with channel dimensions in the micro‐or
millimeter region have found widespread application in organic synthesis. The characteristic …

[HTML][HTML] Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications

B Wiltschi, T Cernava, A Dennig, MG Casas… - Biotechnology …, 2020 - Elsevier
Competitive sustainable production in industry demands new and better biocatalysts,
optimized bioprocesses and cost-effective product recovery. Our review sheds light on the …

Flow biocatalysis: A challenging alternative for the synthesis of APIs and natural compounds

M Santi, L Sancineto, V Nascimento… - International journal of …, 2021 - mdpi.com
Biocatalysts represent an efficient, highly selective and greener alternative to metal catalysts
in both industry and academia. In the last two decades, the interest in biocatalytic …

Microscale technology and biocatalytic processes: opportunities and challenges for synthesis

R Wohlgemuth, I Plazl, P Žnidaršič-Plazl… - Trends in …, 2015 - cell.com
Despite the expanding presence of microscale technology in chemical synthesis and energy
production as well as in biomedical devices and analytical and diagnostic tools, its potential …

Review on hydrodynamics and mass transfer in minichannel wall reactors with gas–liquid Taylor flow

S Haase, DY Murzin, T Salmi - Chemical Engineering Research and …, 2016 - Elsevier
Over the past decades, Taylor flow has got an increasing interest due to its potential to
intensify reaction processes with fast kinetics which are usually controlled by mass transfer …

Process intensification as game changer in enzyme catalysis

BO Burek, AWH Dawood, F Hollmann, A Liese… - Frontiers in …, 2022 - frontiersin.org
Enzyme catalysis, made tremendous progress over the last years in identification of new
enzymes and new enzymatic reactivity's as well as optimization of existing enzymes …

The microenvironment in immobilized enzymes: Methods of characterization and its role in determining enzyme performance

JM Bolivar, B Nidetzky - Molecules, 2019 - mdpi.com
The liquid milieu in which enzymes operate when they are immobilized in solid materials
can be quite different from the milieu in bulk solution. Important differences are in the …

Kontinuierliche Durchflussverfahren: ein Werkzeug für die sichere Synthese von pharmazeutischen Wirkstoffen

B Gutmann, D Cantillo, CO Kappe - Angewandte Chemie, 2015 - Wiley Online Library
In den letzten Jahren haben Durchflussreaktoren mit Kanalabmessungen im Mikrometer‐
oder Millimeterbereich weitverbreitete Anwendung in der organischen Synthese gefunden …

The promises and the challenges of biotransformations in microflow

P Žnidaršič‐Plazl - Biotechnology journal, 2019 - Wiley Online Library
The challenges of transition toward the postpetroleum world shed light on the biocatalysis as
the most sustainable way for the valorization of biobased raw materials. However, its …