▪ Abstract NK cells are regulated by opposing signals from receptors that activate and inhibit
effector function. While positive stimulation may be initiated by an array of co-stimulatory …

HLA class I downregulation is a frequent event associated with tumour invasion and
development. Altered HLA class I tumour phenotypes can have profound effects on T-cell …

The protein HLA-E is a non-classical major histocompatibility complex (MHC) molecule of
limited sequence variability. Its expression on the cell surface is regulated by the binding of …

We previously showed that the availability of a nonamer peptide derived from certain HLA
class I signal sequences is a necessary requirement for the stabilization of endogenous HLA …

The presence and expression of killer inhibitory receptor (KIR) and CD94: NKG2 genes from
68 donors were analyzed using molecular ty** techniques. The genes encoding CD94 …

Natural killer (NK) cells express cell-surface receptors of the immunoglobulin and C-type
lectin superfamilies that recognize major histocompatibility complex (MHC) class I peptides …

Natural killer (NK) cell–mediated lysis is negatively regulated by killer cell inhibitory
receptors specific for major histocompatibility complex (MHC) class I molecules. In this study …

Human histocompatibility leukocyte antigen (HLA)-E is a nonclassical HLA class I molecule,
the gene for which is transcribed in most tissues. It has recently been reported that this …

Human natural killer (NK) cells express several killer cell immunoglobulin (Ig)-like receptors
(KIRs) that inhibit their cytotoxicity upon recognition of human histocompatibility leukocyte …

HLA-G is a nonclassical major histocompatibility complex class I molecule selectively
expressed on cytotrophoblasts at the feto–maternal interface, where it may play an important …