Synthesis of chalcones derivatives and their biological activities: a review

NAA Elkanzi, H Hrichi, RA Alolayan, W Derafa… - ACS …, 2022 - ACS Publications
Chalcone derivatives are considered valuable species because they possess a
ketoethylenic moiety, CO–CH═ CH–. Due to the presence of a reactive α, β-unsaturated …

Antibacterial effects of flavonoids and their structure-activity relationship study: A comparative interpretation

NF Shamsudin, QU Ahmed, S Mahmood, SA Ali Shah… - Molecules, 2022 - mdpi.com
According to the latest report released by the World Health Organization, bacterial
resistance to well-known and widely available antibacterial drugs has become a significant …

[HTML][HTML] Pyrazole and pyrazoline derivatives as antimalarial agents: A key review

L Ravindar, SA Hasbullah, KP Rakesh… - European Journal of …, 2023 - Elsevier
Malaria poses a severe public health risk and a significant economic burden in disease-
endemic countries. One of the most severe issues in malaria control is the development of …

[HTML][HTML] Pharmacotherapeutics applications and chemistry of chalcone derivatives

JS Dhaliwal, S Moshawih, KW Goh, MJ Loy… - Molecules, 2022 - mdpi.com
Chalcones have been well examined in the extant literature and demonstrated antibacterial,
antifungal, anti-inflammatory, and anticancer properties. A detailed evaluation of the …

[HTML][HTML] Chalcone: A promising bioactive scaffold in medicinal chemistry

G Rajendran, D Bhanu, B Aruchamy, P Ramani… - Pharmaceuticals, 2022 - mdpi.com
Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …

Triazole hybrid compounds: A new frontier in malaria treatment

L Ravindar, SA Hasbullah, KP Rakesh… - European journal of …, 2023 - Elsevier
Reviewing the advancements in malaria treatment, the emergence of triazole hybrid
compounds stands out as a groundbreaking development. Combining the advantages of …

Recent developments in antimalarial activities of 4-aminoquinoline derivatives

L Ravindar, SA Hasbullah, KP Rakesh… - European Journal of …, 2023 - Elsevier
Malaria is the fifth most lethal parasitic infection in the world. Antimalarial medications have
played a crucial role in preventing and eradicating malaria. Numerous heterocyclic moieties …

Antibacterial activities of sulfonyl or sulfonamide containing heterocyclic derivatives and its structure-activity relationships (SAR) studies: A critical review

SK Verma, R Verma, F Xue, PK Thakur, YR Girish… - Bioorganic …, 2020 - Elsevier
The rise of drug-resistance has made the deserted clinical requirement to improve of new
classes of antibiotics agents. The development of antibacterial agents with the novel method …

Exploring the antimalarial and antioxidant efficacy of transition metal (II) chelates of thiosemicarbazone ligands: spectral investigations, molecular docking, DFT, MESP …

J Devi, B Kumar, A Dubey, A Tufail, A Boora - Biometals, 2024 - Springer
Malaria, a relentless and ancient adversary, continues to cast its shadow over vast swathes
of the globe, afflicting millions of people and have a heavy toll on human health and well …

Anticancer activity of natural and synthetic chalcones

T Constantinescu, CN Lungu - International journal of molecular sciences, 2021 - mdpi.com
Cancer is a condition caused by many mechanisms (genetic, immune, oxidation, and
inflammatory). Anticancer therapy aims to destroy or stop the growth of cancer cells …