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Computational analysis of cancer genome sequencing data
Distilling biologically meaningful information from cancer genome sequencing data requires
comprehensive identification of somatic alterations using rigorous computational methods …
comprehensive identification of somatic alterations using rigorous computational methods …
Chromothripsis in cancer cells: An update
A Rode, KK Maass, KV Willmund… - … journal of cancer, 2016 - Wiley Online Library
In 2011, a novel form of genome instability was reported by Stephens et al., characterized by
tens to hundreds of locally clustered rearrangements affecting one or a few chromosome (s) …
tens to hundreds of locally clustered rearrangements affecting one or a few chromosome (s) …
Molecular landmarks of tumor hypoxia across cancer types
Many primary-tumor subregions have low levels of molecular oxygen, termed hypoxia.
Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular …
Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular …
Lung neuroendocrine tumours: deep sequencing of the four World Health Organization histotypes reveals chromatin‐remodelling genes as major players and a …
Next‐generation sequencing (NGS) was applied to 148 lung neuroendocrine tumours
(LNETs) comprising the four World Health Organization classification categories: 53 typical …
(LNETs) comprising the four World Health Organization classification categories: 53 typical …