Development and arealization of the cerebral cortex

CR Cadwell, A Bhaduri, MA Mostajo-Radji, MG Keefe… - Neuron, 2019 - cell.com
Adult cortical areas consist of specialized cell types and circuits that support unique higher-
order cognitive functions. How this regional diversity develops from an initially uniform …

How development sculpts hippocampal circuits and function

R Cossart, R Khazipov - Physiological Reviews, 2022 - journals.physiology.org
In mammals, the selective transformation of transient experience into stored memory occurs
in the hippocampus, which develops representations of specific events in the context in …

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

JJ Lee, R Wedow, A Okbay, E Kong, O Maghzian… - Nature …, 2018 - nature.com
Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …

Multi-stage differentiation defines melanoma subtypes with differential vulnerability to drug-induced iron-dependent oxidative stress

J Tsoi, L Robert, K Paraiso, C Galvan, KM Sheu, J Lay… - Cancer cell, 2018 - cell.com
Malignant transformation can result in melanoma cells that resemble different stages of their
embryonic development. Our gene expression analysis of human melanoma cell lines and …

Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex

TJ Nowakowski, A Bhaduri, AA Pollen, B Alvarado… - Science, 2017 - science.org
Systematic analyses of spatiotemporal gene expression trajectories during organogenesis
have been challenging because diverse cell types at different stages of maturation and …

Mitochondrial dynamics in postmitotic cells regulate neurogenesis

R Iwata, P Casimir, P Vanderhaeghen - Science, 2020 - science.org
The conversion of neural stem cells into neurons is associated with the remodeling of
organelles, but whether and how this is causally linked to fate change is poorly understood …

Temporal control of mammalian cortical neurogenesis by m6A methylation

KJ Yoon, FR Ringeling, C Vissers, F Jacob, M Pokrass… - Cell, 2017 - cell.com
Summary N 6-methyladenosine (m 6 A), installed by the Mettl3/Mettl14 methyltransferase
complex, is the most prevalent internal mRNA modification. Whether m 6 A regulates …

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

S Marques, A Zeisel, S Codeluppi, D Van Bruggen… - Science, 2016 - science.org
Oligodendrocytes have been considered as a functionally homogeneous population in the
central nervous system (CNS). We performed single-cell RNA sequencing on 5072 cells of …
L Telley, G Agirman, J Prados, N Amberg, S Fièvre… - Science, 2019 - science.org
INTRODUCTION The cerebral cortex is a cellularly heterogeneous structure whose
neuronal circuits underlie high-order cognitive and sensorimotor information processing …

Developmental diversification of cortical inhibitory interneurons

C Mayer, C Hafemeister, RC Bandler, R Machold… - Nature, 2018 - nature.com
Diverse subsets of cortical interneurons have vital roles in higher-order brain functions. To
investigate how this diversity is generated, here we used single-cell RNA sequencing to …