Redox signaling in cardiac physiology and pathology
Redox signaling refers to the specific and usually reversible oxidation/reduction modification
of molecules involved in cellular signaling pathways. In the heart, redox signaling regulates …
of molecules involved in cellular signaling pathways. In the heart, redox signaling regulates …
cAMP signaling in subcellular compartments
K Lefkimmiatis, M Zaccolo - Pharmacology & therapeutics, 2014 - Elsevier
In the complex microcosm of a cell, information security and its faithful transmission are
critical for maintaining internal stability. To achieve a coordinated response of all its parts to …
critical for maintaining internal stability. To achieve a coordinated response of all its parts to …
Hydrogen peroxide sensing and signaling by protein kinases in the cardiovascular system
JR Burgoyne, S Oka, N Ale-Agha… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: Oxidants were once principally considered perpetrators of injury and disease.
However, this has become an antiquated view, with cumulative evidence showing that the …
However, this has become an antiquated view, with cumulative evidence showing that the …
Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart
AT Akhmedov, V Rybin, J Marín-García - Heart failure reviews, 2015 - Springer
Despite significant progress in cardiovascular medicine, myocardial ischemia and infarction,
progressing eventually to the final end point heart failure (HF), remain the leading cause of …
progressing eventually to the final end point heart failure (HF), remain the leading cause of …
Blood pressure–lowering by the antioxidant resveratrol is counterintuitively mediated by oxidation of cGMP-dependent protein kinase
Background: The health-promoting and disease-limiting abilities of resveratrol, a natural
polyphenol, has led to considerable interest in understanding the mechanisms of its …
polyphenol, has led to considerable interest in understanding the mechanisms of its …
Oxidation of protein kinase A regulatory subunit PKARIα protects against myocardial ischemia-reperfusion injury by inhibiting lysosomal-triggered calcium release
JN Simon, B Vrellaku, S Monterisi, SM Chu… - Circulation, 2021 - Am Heart Assoc
Background: Kinase oxidation is a critical signaling mechanism through which changes in
the intracellular redox state alter cardiac function. In the myocardium, PKARIα (type-1 protein …
the intracellular redox state alter cardiac function. In the myocardium, PKARIα (type-1 protein …
S-nitrosylation is required for β2AR desensitization and experimental asthma
FV Fonseca, TM Raffay, K ** cardiac action
potentials (APs) and increased I NaL is associated with cardiac arrhythmias. β-adrenergic …
potentials (APs) and increased I NaL is associated with cardiac arrhythmias. β-adrenergic …
Protein kinase G Iα oxidation paradoxically underlies blood pressure lowering by the reductant hydrogen sulfide
Dysregulated blood pressure control leading to hypertension is prevalent and is a risk factor
for several common diseases. Fully understanding blood pressure regulation offers the …
for several common diseases. Fully understanding blood pressure regulation offers the …
S-nitrosylation of calcium-handling proteins in cardiac adrenergic signaling and hypertrophy
Rationale: The regulation of calcium (Ca2+) homeostasis by β-adrenergic receptor (βAR)
activation provides the essential underpinnings of sympathetic regulation of myocardial …
activation provides the essential underpinnings of sympathetic regulation of myocardial …