The use of animal models, particularly genetically modified mice, continues to play a critical
role in studying the relationship between bile acid metabolism and human liver disease …

Cholestatic liver disease denotes any situation associated with impaired bile flow
concomitant with a noxious bile acid accumulation in the liver and/or systemic circulation …

Bariatric surgical procedures such as sleeve gastrectomy (SG) provide effective type 2
diabetes (T2D) remission in human patients. Previous work demonstrated that …

Lithocholic acid (LCA) is both a secondary bile acid and a vitamin D receptor (VDR) ligand.
The VDR is activated by 1, 25-dihydroxy vitamin D 3 and plays an important role in …

Accumulation of bile acids is a major mediator of cholestatic liver injury. Recent studies
indicate bile acid composition between humans and rodents is dramatically different, as …

Bile acids are important hydroxylated steroids that are synthesized in the liver from
cholesterol for intestinal absorption of lipids and other fatty-nutrient. They also display …

Background: There is growing recognition of the significance of the gut microbiome to
human health, and the association between a perturbed gut microbiome with human …

Bile acids are microbial metabolites that can impact infection of enteric and hepatitis viruses,
but their functions during systemic viral infection remain unclear. Here we show that …

The main trigger for liver injury in acquired cholestatic liver disease remains unclear.
However, the accumulation of bile acids (BAs) undoubtedly plays a role. Recent progress in …

A 9‐week feeding experiment was conducted to investigate the effects of dietary bile acids
(BA s) on juvenile genetically improved farmed tilapia (GIFT)(Oreochromis niloticus) based …