Develo** biomedical engineering technologies for reproductive medicine

Y Zhu, B Kong, R Liu, Y Zhao - Smart Medicine, 2022 - Wiley Online Library
Infertility is a rising global health issue with a far‐reaching impact on the socioeconomic
livelihoods. As there are highly complex causes of male and female infertility, it is highly …

Engineered stem cell-based strategy: a new paradigm of next-generation stem cell product in regenerative medicine

H Han, BT Chen, Y Liu, Y Wang, L **ng, H Wang… - Journal of Controlled …, 2024 - Elsevier
Stem cells have garnered significant attention in regenerative medicine owing to their
abilities of multi-directional differentiation and self-renewal. Despite these encouraging …

[HTML][HTML] Exosomes–Spectacular role in reproduction

A Kowalczyk, M Wrzecińska… - Biomedicine & …, 2022 - Elsevier
Exosomes are nano-sized structures that are found in semen, epididymal–fluid,
endometrium, as well as in follicular fluid. They are responsible for transporting bioactive …

The renaissance of male infertility management in the golden age of andrology

AE Calogero, R Cannarella, A Agarwal… - The world journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Infertility affects nearly 186 million people worldwide and the male partner is the cause in
about half of the cases. Meta-regression data indicate an unexplained decline in sperm …

Understanding testicular single cell transcriptional atlas: from developmental complications to male infertility

MB Tirumalasetty, I Bhattacharya… - Frontiers in …, 2024 - frontiersin.org
Spermatogenesis is a multi-step biological process where mitotically active diploid (2n)
spermatogonia differentiate into haploid (n) spermatozoa via regulated meiotic …

Very small embryonic-like stem cells (VSELs) regenerate whereas mesenchymal stromal cells (MSCs) rejuvenate diseased reproductive tissues

D Bhartiya, P Singh, D Sharma, A Kaushik - Stem Cell Reviews and …, 2022 - Springer
Compared to embryonic and induced pluripotent stem cells, mesenchymal stem/stromal
cells (MSCs) have made their presence felt with good therapeutic promise and safety profile …

[HTML][HTML] Effect of monosodium glutamate on serum sex hormones and uterine histology in female rats along with its molecular docking and in-silico toxicity

MAM Abdulghani, SA Alshehade, S Kamran… - Heliyon, 2022 - cell.com
Monosodium glutamate (MSG) is commonly used worldwide as a food flavour enhancer by
the food industry. The current study investigated the in vivo toxic effects of MSG on the uterus …

A pumpless monolayer microfluidic device based on mesenchymal stem cell-conditioned medium promotes neonatal mouse in vitro spermatogenesis

S Önen, AC Atik, M Gizer, S Köse, Ö Yaman… - Stem Cell Research & …, 2023 - Springer
Background Childhood cancer treatment-induced gonadotoxicity causes permanent
infertility/sub-infertility in nearly half of males. The current clinical and experimental …

Deciphering the molecular characteristics of human idiopathic nonobstructive azoospermia from the perspective of germ cells

Y Chen, X Liu, L Zhang, F Zhu, L Yan… - Advanced …, 2023 - Wiley Online Library
Nonobstructive azoospermia (NOA) is one of the most important causes of male infertility,
accounting for 10–15% of infertile men worldwide. Among these, more than 70% of cases …

[HTML][HTML] Cellular therapy via spermatogonial stem cells for treating impaired spermatogenesis, non-obstructive azoospermia

NE Abdelaal, BM Tanga, M Abdelgawad, S Allam… - Cells, 2021 - mdpi.com
Male infertility is a major health problem affecting about 8–12% of couples worldwide.
Spermatogenesis starts in the early fetus and completes after puberty, passing through …