Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank
Abstract The UK Biobank Exome Sequencing Consortium (UKB-ESC) is a private–public
partnership between the UK Biobank (UKB) and eight biopharmaceutical companies that …
partnership between the UK Biobank (UKB) and eight biopharmaceutical companies that …
Reaching the end-game for GWAS: machine learning approaches for the prioritization of complex disease loci
Genome-wide association studies (GWAS) have revealed thousands of genetic loci that
underpin the complex biology of many human traits. However, the strength of GWAS–the …
underpin the complex biology of many human traits. However, the strength of GWAS–the …
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Behaviors and disorders related to self-regulation, such as substance use, antisocial
behavior and attention-deficit/hyperactivity disorder, are collectively referred to as …
behavior and attention-deficit/hyperactivity disorder, are collectively referred to as …
Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images
Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
MK Bakker, RAA van der Spek, W van Rheenen… - Nature …, 2020 - nature.com
Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of
stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we …
stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we …
Causal influences of neuroticism on mental health and cardiovascular disease
We investigated the relationship between neuroticism and 16 mental and 18 physical traits
using summary results of genome-wide association studies for these traits. LD score …
using summary results of genome-wide association studies for these traits. LD score …
Genoty** and population characteristics of the China Kadoorie Biobank
Summary The China Kadoorie Biobank (CKB) is a population-based prospective cohort of>
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …
Study profile of the Tohoku medical megabank community-based cohort study
A Hozawa, K Tanno, N Nakaya, T Nakamura… - Journal of …, 2021 - jstage.jst.go.jp
Background: We established a community-based cohort study to assess the long-term
impact of the Great East Japan Earthquake on disaster victims and gene-environment …
impact of the Great East Japan Earthquake on disaster victims and gene-environment …
Importance of including non-European populations in large human genetic studies to enhance precision medicine
One goal of genomic medicine is to uncover an individual's genetic risk for disease, which
generally requires data connecting genotype to phenotype, as done in genome-wide …
generally requires data connecting genotype to phenotype, as done in genome-wide …
Identification of risk loci for primary aldosteronism in genome-wide association studies
E Le Floch, T Cosentino, CK Larsen… - Nature …, 2022 - nature.com
Primary aldosteronism affects up to 10% of hypertensive patients and is responsible for
treatment resistance and increased cardiovascular risk. Here we perform a genome-wide …
treatment resistance and increased cardiovascular risk. Here we perform a genome-wide …