The R language: an engine for bioinformatics and data science
The R programming language is approaching its 30th birthday, and in the last three decades
it has achieved a prominent role in statistics, bioinformatics, and data science in general. It …
it has achieved a prominent role in statistics, bioinformatics, and data science in general. It …
Ten quick tips for machine learning in computational biology
D Chicco - BioData mining, 2017 - Springer
Abstract Machine learning has become a pivotal tool for many projects in computational
biology, bioinformatics, and health informatics. Nevertheless, beginners and biomedical …
biology, bioinformatics, and health informatics. Nevertheless, beginners and biomedical …
Identification of functional heterogeneity of carcinoma-associated fibroblasts with distinct IL6-mediated therapy resistance in pancreatic cancer
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) involves a
significant accumulation of fibroblasts as part of the host response to cancer. Using single …
significant accumulation of fibroblasts as part of the host response to cancer. Using single …
Human gut bacteria produce ΤΗ17-modulating bile acid metabolites
The microbiota modulates gut immune homeostasis. Bacteria influence the development
and function of host immune cells, including T helper cells expressing interleukin-17A (TH17 …
and function of host immune cells, including T helper cells expressing interleukin-17A (TH17 …
[HTML][HTML] Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer
T cell exhaustion is a major impediment to antitumor immunity. However, it remains elusive
how other immune cells in the tumor microenvironment (TME) contribute to this dysfunctional …
how other immune cells in the tumor microenvironment (TME) contribute to this dysfunctional …
Oncogene-like addiction to aneuploidy in human cancers
Most cancers exhibit aneuploidy, but its functional significance in tumor development is
controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using …
controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using …
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
DVF Tauriello, S Palomo-Ponce, D Stork… - Nature, 2018 - nature.com
Most patients with colorectal cancer die as a result of the disease spreading to other organs.
However, no prevalent mutations have been associated with metastatic colorectal cancers …
However, no prevalent mutations have been associated with metastatic colorectal cancers …
Silhouette analysis for performance evaluation in machine learning with applications to clustering
Grou** the objects based on their similarities is an important common task in machine
learning applications. Many clustering methods have been developed, among them k …
learning applications. Many clustering methods have been developed, among them k …
Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma
An effective blood-based method for the diagnosis and prognosis of hepatocellular
carcinoma (HCC) has not yet been developed. Circulating tumour DNA (ctDNA) carrying …
carcinoma (HCC) has not yet been developed. Circulating tumour DNA (ctDNA) carrying …
A systematic evaluation of single-cell RNA-sequencing imputation methods
Background The rapid development of single-cell RNA-sequencing (scRNA-seq)
technologies has led to the emergence of many methods for removing systematic technical …
technologies has led to the emergence of many methods for removing systematic technical …