Dual‐specificity tyrosine‐regulated kinases (DYRKs) comprise a family of protein kinases
within the CMGC group of the eukaryotic kinome. Members of the DYRK family are found in …

The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system
(CNS) during development and aging. This review analyzes the functions of this kinase by …

Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21). DS is a gene
dosage disorder that results in multiple phenotypes including congenital heart defects. This …

Down syndrome (DS) is one of the leading causes of intellectual disability, and patients with
DS face various health issues, including learning and memory deficits, congenital heart …

DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …

Dual‐specificity tyrosine phosphorylation‐regulated kinase 1A (DYRK1A) is a protein kinase
with diverse functions in neuronal development and adult brain physiology. Higher than …

MNB/DYRK1A is a member of the dual‐specificity tyrosine phosphorylation‐regulated
kinase (DYRK) family that has been strongly conserved across evolution. There are …

Leucettinibs are substituted 2-aminoimidazolin-4-ones (inspired by the marine sponge
natural product Leucettamine B) developed as pharmacological inhibitors of DYRK1A (dual …

Protein kinases are one of the most studied drug targets in current pharmacological
research, as evidenced by the vast number of kinase-targeting agents enrolled in active …

Down syndrome is the main cause of intellectual disabilities with a large set of comorbidities
from developmental origins but also that appeared across life span. Investigation of the …