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Advancing drug safety science by integrating molecular knowledge with post‐marketing adverse event reports
Promising drug development efforts may frequently fail due to unintended adverse reactions.
Several methods have been developed to analyze such data, aiming to improve …
Several methods have been developed to analyze such data, aiming to improve …
[HTML][HTML] Radioimmunotherapy in non-Hodgkin's lymphoma: retrospective adverse event profiling of Zevalin and Bexxar
The development of monoclonal antibodies has dramatically changed the outcome of
patients with non-Hodgkin's lymphoma (NHL), the most common hematological malignancy …
patients with non-Hodgkin's lymphoma (NHL), the most common hematological malignancy …
Primary T‐cell‐based delivery platform for in vivo synthesis of engineered proteins
H Radhakrishnan, SL Newmyer… - Bioengineering & …, 2024 - Wiley Online Library
Primary T cell has been transformed into a cell‐based delivery platform that synthesizes
complex biologics at the disease site with spatiotemporal resolution. This broadly applicable …
complex biologics at the disease site with spatiotemporal resolution. This broadly applicable …
Whole patient knowledge modeling of COVID-19 symptomatology reveals common molecular mechanisms
Infection with SARS-CoV-2 coronavirus causes systemic, multi-faceted COVID-19 disease.
However, knowledge connecting its intricate clinical manifestations with molecular …
However, knowledge connecting its intricate clinical manifestations with molecular …
Drug–drug interactions in patients undergoing chemoradiotherapy and the impact of an expert team intervention
SJV Daggupati, PUP Saxena, A Kamath… - International Journal of …, 2020 - Springer
Background Several studies have examined the drug–drug interaction patterns in different
patient populations and treatment settings; however, there is a need, particularly in the field …
patient populations and treatment settings; however, there is a need, particularly in the field …
The COVID-19 explorer—An integrated, whole patient knowledge model of COVID-19 disease
Since early 2020 the COVID-19 pandemic has paralyzed the world, resulting in more than
half a billion infections and over 6 million deaths within a 28-month period. Knowledge …
half a billion infections and over 6 million deaths within a 28-month period. Knowledge …
Application of a patient‐centered reverse translational systems‐based approach to understand mechanisms of an adverse drug reaction of immune checkpoint …
S Kim, G Lahu, M Vakilynejad… - Clinical and …, 2022 - Wiley Online Library
Immunotherapy became a key pillar of cancer therapeutics with the approvals of ipilimumab,
nivolumab, and pembrolizumab, which inhibit either cytotoxic T‐lymphocyte antigen‐4 …
nivolumab, and pembrolizumab, which inhibit either cytotoxic T‐lymphocyte antigen‐4 …
A case study of a patient‐centered reverse translational systems‐based approach to understand adverse event profiles in drug development
S Kim, G Lahu, M Vakilynejad… - Clinical and …, 2022 - Wiley Online Library
Adverse drug reactions (ADRs) of targeted therapy drugs (TTDs) are frequently unexpected
and long‐term toxicities detract from exceptional efficacy of new TTDs. In this proof‐of …
and long‐term toxicities detract from exceptional efficacy of new TTDs. In this proof‐of …
Defining Medication Errors, Prescribing Errors, and Adverse Drug Events: A Narrative Review
A Nouri, N Lamfon, G Silsilah… - Palestinian Medical …, 2024 - pmpj.najah.edu
Background: Medication errors, prescribing errors, adverse drug events (ADEs), and side
effects are critical aspects of drug-related patient safety. These errors can occur at various …
effects are critical aspects of drug-related patient safety. These errors can occur at various …
Public adverse event data insights into the safety of pembrolizumab in melanoma patients
A Schaefer, C Sachpekidis, F Diella, A Doerks… - Cancers, 2020 - mdpi.com
Immune checkpoint inhibition represents an important therapeutic option for advanced
melanoma patients. Results from clinical studies have shown that treatment with the PD-1 …
melanoma patients. Results from clinical studies have shown that treatment with the PD-1 …