Advancing drug safety science by integrating molecular knowledge with post‐marketing adverse event reports

TG Soldatos, S Kim, S Schmidt… - CPT …, 2022 - Wiley Online Library
Promising drug development efforts may frequently fail due to unintended adverse reactions.
Several methods have been developed to analyze such data, aiming to improve …

[HTML][HTML] Radioimmunotherapy in non-Hodgkin's lymphoma: retrospective adverse event profiling of Zevalin and Bexxar

C Sachpekidis, DB Jackson, TG Soldatos - Pharmaceuticals, 2019 - mdpi.com
The development of monoclonal antibodies has dramatically changed the outcome of
patients with non-Hodgkin's lymphoma (NHL), the most common hematological malignancy …

Primary T‐cell‐based delivery platform for in vivo synthesis of engineered proteins

H Radhakrishnan, SL Newmyer… - Bioengineering & …, 2024 - Wiley Online Library
Primary T cell has been transformed into a cell‐based delivery platform that synthesizes
complex biologics at the disease site with spatiotemporal resolution. This broadly applicable …

Whole patient knowledge modeling of COVID-19 symptomatology reveals common molecular mechanisms

S Brock, DB Jackson, TG Soldatos… - Frontiers in Molecular …, 2023 - frontiersin.org
Infection with SARS-CoV-2 coronavirus causes systemic, multi-faceted COVID-19 disease.
However, knowledge connecting its intricate clinical manifestations with molecular …

Drug–drug interactions in patients undergoing chemoradiotherapy and the impact of an expert team intervention

SJV Daggupati, PUP Saxena, A Kamath… - International Journal of …, 2020 - Springer
Background Several studies have examined the drug–drug interaction patterns in different
patient populations and treatment settings; however, there is a need, particularly in the field …

The COVID-19 explorer—An integrated, whole patient knowledge model of COVID-19 disease

S Brock, TG Soldatos, DB Jackson, F Diella… - Frontiers in Molecular …, 2022 - frontiersin.org
Since early 2020 the COVID-19 pandemic has paralyzed the world, resulting in more than
half a billion infections and over 6 million deaths within a 28-month period. Knowledge …

Application of a patient‐centered reverse translational systems‐based approach to understand mechanisms of an adverse drug reaction of immune checkpoint …

S Kim, G Lahu, M Vakilynejad… - Clinical and …, 2022 - Wiley Online Library
Immunotherapy became a key pillar of cancer therapeutics with the approvals of ipilimumab,
nivolumab, and pembrolizumab, which inhibit either cytotoxic T‐lymphocyte antigen‐4 …

A case study of a patient‐centered reverse translational systems‐based approach to understand adverse event profiles in drug development

S Kim, G Lahu, M Vakilynejad… - Clinical and …, 2022 - Wiley Online Library
Adverse drug reactions (ADRs) of targeted therapy drugs (TTDs) are frequently unexpected
and long‐term toxicities detract from exceptional efficacy of new TTDs. In this proof‐of …

Defining Medication Errors, Prescribing Errors, and Adverse Drug Events: A Narrative Review

A Nouri, N Lamfon, G Silsilah… - Palestinian Medical …, 2024 - pmpj.najah.edu
Background: Medication errors, prescribing errors, adverse drug events (ADEs), and side
effects are critical aspects of drug-related patient safety. These errors can occur at various …

Public adverse event data insights into the safety of pembrolizumab in melanoma patients

A Schaefer, C Sachpekidis, F Diella, A Doerks… - Cancers, 2020 - mdpi.com
Immune checkpoint inhibition represents an important therapeutic option for advanced
melanoma patients. Results from clinical studies have shown that treatment with the PD-1 …