Genome-wide association studies for complex traits: consensus, uncertainty and challenges
The past year has witnessed substantial advances in understanding the genetic basis of
many common phenotypes of biomedical importance. These advances have been the result …
many common phenotypes of biomedical importance. These advances have been the result …
Linkage disequilibrium—understanding the evolutionary past and map** the medical future
M Slatkin - Nature Reviews Genetics, 2008 - nature.com
Linkage disequilibrium—the nonrandom association of alleles at different loci—is a sensitive
indicator of the population genetic forces that structure a genome. Because of the explosive …
indicator of the population genetic forces that structure a genome. Because of the explosive …
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
Genome-wide association studies (GWAS) and large-scale replication studies have
identified common variants in 79 loci associated with breast cancer, explaining∼ 14% of the …
identified common variants in 79 loci associated with breast cancer, explaining∼ 14% of the …
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer
Most common breast cancer susceptibility variants have been identified through genome-
wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease …
wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease …
[HTML][HTML] The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
… -6 Receptor Mendelian Randomisation Analysis (IL6R … - The Lancet, 2012 - Elsevier
BACKGROUND: A high circulating concentration of interleukin 6 is associated with
increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a …
increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a …
Large-scale genoty** identifies 41 new loci associated with breast cancer risk
Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …
been identified as associated with susceptibility to breast cancer, and these account for∼ …
The landscape of long noncoding RNAs in the human transcriptome
Long noncoding RNAs (lncRNAs) are emerging as important regulators of tissue physiology
and disease processes including cancer. To delineate genome-wide lncRNA expression …
and disease processes including cancer. To delineate genome-wide lncRNA expression …
STrengthening the REporting of Genetic Association Studies (STREGA)—an extension of the STROBE statement
Making sense of rapidly evolving evidence on genetic associations is crucial to making
genuine advances in human genomics and the eventual integration of this information in the …
genuine advances in human genomics and the eventual integration of this information in the …
How to interpret a genome-wide association study
TA Pearson, TA Manolio - Jama, 2008 - jamanetwork.com
Genome-wide association (GWA) studies use high-throughput genoty** technologies to
assay hundreds of thousands of single-nucleotide polymorphisms (SNPs) and relate them to …
assay hundreds of thousands of single-nucleotide polymorphisms (SNPs) and relate them to …
[HTML][HTML] Breast cancer: origins and evolution
K Polyak - The Journal of clinical investigation, 2007 - Am Soc Clin Investig
Breast cancer is not a single disease, but rather is composed of distinct subtypes associated
with different clinical outcomes. Understanding this heterogeneity is key for the development …
with different clinical outcomes. Understanding this heterogeneity is key for the development …