Deptor: not only a mTOR inhibitor
V Catena, M Fanciulli - Journal of Experimental & Clinical Cancer …, 2017 - Springer
Deptor is an important protein that belongs to the mTORC1 and mTORC2 complexes, able
to interact with mTOR and to inhibit its kinase activity. As a natural mTOR inhibitor, Deptor is …
to interact with mTOR and to inhibit its kinase activity. As a natural mTOR inhibitor, Deptor is …
Targeting mTOR in acute lymphoblastic leukemia
C Simioni, AM Martelli, G Zauli, E Melloni, LM Neri - Cells, 2019 - mdpi.com
Acute Lymphoblastic Leukemia (ALL) is an aggressive hematologic disorder and constitutes
approximately 25% of cancer diagnoses among children and teenagers. Pediatric patients …
approximately 25% of cancer diagnoses among children and teenagers. Pediatric patients …
The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells
S Zhang, X You, Y Zheng, Y Shen… - The Journal of …, 2023 - Am Soc Clin Investig
Ubiquitin-conjugating enzyme E2C (UBE2C) mediates ubiquitylation chain formation via the
K11 linkage. While previous in vitro studies showed that UBE2C plays a growth-promoting …
K11 linkage. While previous in vitro studies showed that UBE2C plays a growth-promoting …
Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is commonly driven by activating mutations in
NOTCH1 that facilitate glutamine oxidation. Here we identify oxidative phosphorylation …
NOTCH1 that facilitate glutamine oxidation. Here we identify oxidative phosphorylation …
Direct phosphorylation and stabilization of MYC by aurora B kinase promote T-cell leukemogenesis
J Jiang, J Wang, M Yue, X Cai, T Wang, C Wu, H Su… - Cancer Cell, 2020 - cell.com
Deregulation of MYC plays an essential role in T cell acute lymphoblastic leukemia (T-ALL),
yet the mechanisms underlying its deregulation remain elusive. Herein, we identify a …
yet the mechanisms underlying its deregulation remain elusive. Herein, we identify a …
[HTML][HTML] Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling
T Lan, Y Hu, F Hu, H Li, Y Chen, J Zhang, Y Yu… - Journal of …, 2022 - Elsevier
Abstract Background & Aims Nonalcoholic fatty liver disease (NAFLD) has become the most
common chronic liver diseases worldwide. The advantage stage of NAFLD, nonalcoholic …
common chronic liver diseases worldwide. The advantage stage of NAFLD, nonalcoholic …
PUM1 Promotes Tumor Progression by Activating DEPTOR‐Meditated Glycolysis in Gastric Cancer
S Yin, H Liu, Z Zhou, X Xu, P Wang, W Chen… - Advanced …, 2023 - Wiley Online Library
RNA‐binding proteins (RBPs) play essential roles in tumorigenesis and progression, but
their functions in gastric cancer (GC) remain largely elusive. Here, it is reported that Pumilio …
their functions in gastric cancer (GC) remain largely elusive. Here, it is reported that Pumilio …
DEPTOR at the nexus of cancer, metabolism, and immunity
DEP domain-containing mechanistic target of rapamycin (mTOR)-interacting protein
(DEPTOR) is an important modulator of mTOR, a kinase at the center of two important …
(DEPTOR) is an important modulator of mTOR, a kinase at the center of two important …
Assessment of the clinical utility of four NGS panels in myeloid malignancies. Suggestions for NGS panel choice or design
A Aguilera-Diaz, I Vazquez, B Ariceta, A Mañú… - PloS one, 2020 - journals.plos.org
The diagnosis of myeloid neoplasms (MN) has significantly evolved through the last few
decades. Next Generation Sequencing (NGS) is gradually becoming an essential tool to …
decades. Next Generation Sequencing (NGS) is gradually becoming an essential tool to …
Therapeutic targeting of mTOR in T-cell acute lymphoblastic leukemia: an update
C Evangelisti, F Chiarini, JA McCubrey… - International journal of …, 2018 - mdpi.com
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood malignancy that arises
from the clonal expansion of transformed T-cell precursors. Although T-ALL prognosis has …
from the clonal expansion of transformed T-cell precursors. Although T-ALL prognosis has …