Alzheimer's disease, obesity-related metabolic syndrome, and cancer are the leading
causes of death and among the most costly medical conditions in the Western world. In all …

Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …

Although recent clinical trials targeting amyloid-β in Alzheimer's disease have shown
promising results, there is increasing evidence suggesting that understanding alternative …

Loss of function of TREM2, a key receptor selectively expressed by microglia in the brain,
contributes to the development of Alzheimer's disease (AD). We therefore examined whether …

Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor
expressed by macrophages and microglia in the central nervous system (CNS). TREM2 has …

Alzheimer's disease (AD) is the leading cause of dementia worldwide. The extracellular
deposits of Amyloid beta (Aβ) in the brain—called amyloid plaques, and neurofibrillary …

Objective Alzheimer disease (AD) is characterized by amyloid β (Aβ) plaques and
neurofibrillary tau tangles, but increasing evidence suggests that neuroinflammation also …

Triggering receptor expressed on myeloid cells 2 (TREM2) is a receptor mainly expressed
on the surface of microglia. It mediates multiple pathophysiological processes in various …

BACKGROUND Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) plays
an important role in the clearance of pathological amyloid-β (Aβ) in Alzheimer's disease …

Microglia and macrophages are pivotal to the brain's innate immune response and have
garnered considerable attention in the context of glioblastoma (GBM) and Alzheimer's …