Critical reanalysis of the mechanisms underlying the cardiorenal benefits of SGLT2 inhibitors and reaffirmation of the nutrient deprivation signaling/autophagy …

M Packer - Circulation, 2022 - Am Heart Assoc
SGLT2 (sodium-glucose cotransporter 2) inhibitors produce a distinctive pattern of benefits
on the evolution and progression of cardiomyopathy and nephropathy, which is …

Non-alcoholic fatty liver disease (NAFLD) pathogenesis and natural products for prevention and treatment

X Guo, X Yin, Z Liu, J Wang - International journal of molecular sciences, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease,
affecting approximately one-quarter of the global population, and has become a world public …

Endoplasmic reticulum stress in liver diseases

A Ajoolabady, N Kaplowitz, C Lebeaupin, G Kroemer… - Hepatology, 2023 - journals.lww.com
The endoplasmic reticulum (ER) is an intracellular organelle that fosters the correct folding
of linear polypeptides and proteins, a process tightly governed by the ER‐resident enzymes …

Empagliflozin attenuates cardiac microvascular ischemia/reperfusion injury through improving mitochondrial homeostasis

R Zou, W Shi, J Qiu, N Zhou, N Du, H Zhou… - Cardiovascular …, 2022 - Springer
Background Empagliflozin has been reported to protect endothelial cell function, regardless
of diabetes status. However, the role of empagliflozin in microvascular protection during …

Inflammation and oxidative stress in diabetic kidney disease: the targets for SGLT2 inhibitors and GLP-1 receptor agonists

A Winiarska, M Knysak, K Nabrdalik… - International Journal of …, 2021 - mdpi.com
The incidence of type 2 diabetes (T2D) has been increasing worldwide, and diabetic kidney
disease (DKD) remains one of the leading long-term complications of T2D. Several lines of …

SGLT-2 inhibitors in NAFLD: expanding their role beyond diabetes and cardioprotection

T Androutsakos, N Nasiri-Ansari, AD Bakasis… - International journal of …, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is an 'umbrella'term, comprising a spectrum
ranging from benign, liver steatosis to non-alcoholic steatohepatitis, liver fibrosis and …

Genetic and diet-induced animal models for non-alcoholic fatty liver disease (NAFLD) research

CM Flessa, N Nasiri-Ansari, I Kyrou, BM Leca… - International Journal of …, 2022 - mdpi.com
A rapidly increasing incidence of non-alcoholic fatty liver disease (NAFLD) is noted
worldwide due to the adoption of western-type lifestyles and eating habits. This makes the …

[HTML][HTML] Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress

A Abulikemu, X Zhao, H Xu, Y Li, R Ma, Q Yao, J Wang… - Redox Biology, 2023 - Elsevier
The metabolic associated fatty liver disease (MAFLD) is a public health challenge, leading to
a global increase in chronic liver disease. The respiratory exposure of silica nanoparticles …

Endothelial cell dysfunction and nonalcoholic fatty liver disease (NAFLD): A concise review

N Nasiri-Ansari, T Androutsakos, CM Flessa, I Kyrou… - Cells, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases
worldwide. It is strongly associated with obesity, type 2 diabetes (T2DM), and other …

Mitochondria related cell death modalities and disease

C Tian, Y Liu, Z Li, P Zhu, M Zhao - Frontiers in Cell and …, 2022 - frontiersin.org
Mitochondria are well known as the centre of energy metabolism in eukaryotic cells.
However, they can not only generate ATP through the tricarboxylic acid cycle and oxidative …