Detection and remediation of chiral pharmaceuticals from wastewater: A review

VK Vashistha - Chirality, 2022 - Wiley Online Library
Chiral organic pollutants including pharmaceuticals, pesticides, herbicides, flame retardants,
and polycyclic musk cause significant risks to both the environment and human health …

Analytical methodologies for the stereoselective determination of fluoxetine: An overview

G Hancu, M Cârcu‐Dobrin, M Budău… - Biomedical …, 2018 - Wiley Online Library
Fluoxetine is a widely used antidepressant belonging to the selective serotonin reuptake
inhibitor class; it is used in the treatment of major depression, obsessive compulsive …

(RS)‐Propranolol: enantioseparation by HPLC using newly synthesized (S)‐levofloxacin‐based reagent, absolute configuration of diastereomers and recovery of …

S Alwera, R Bhushan - Biomedical Chromatography, 2016 - Wiley Online Library
Diastereomers of (RS)‐propranolol were synthesized using (S)‐levofloxacin‐based new
chiral derivatizing reagents (CDRs). Levofloxacin was chosen as the pure (S)‐enantiomer …

New TLC method combined with densitometry for determination of sertraline and fluoxetine in pharmaceutical preparations

A Pyka-Pająk - Processes, 2022 - mdpi.com
TLC combined with densitometry was used, and chromatographic conditions were
developed to determination both fluoxetine and sertraline in pharmaceuticals. The mobile …

RP‐HPLC enantioseparation of β‐adrenolytics using micellar mobile phase without organic solvents

S Alwera, R Bhushan - Biomedical Chromatography, 2017 - Wiley Online Library
Enantioseparation of a few commonly administered racemic β‐adrenolytics (namely,
carvedilol, betaxolol, salbutamol and bisoprolol) has been achieved using a water micellar …

An innovative combination of molecular modeling and green analysis approaches for the enantioseparation and quantitation of certain CNS acting drugs using HPLC

OA Saleh, AM Badawey, HYA Enein… - Microchemical Journal, 2024 - Elsevier
Enantioseparation of three antidepressants from a group called serotonin and noradrenaline
reuptake inhibitor (SNRIS) was investigated on chiral stationary phases; Lux-Amylose-2 …

Synthesis of diastereomeric anhydrides of (RS)-ketorolac and (RS)-etodolac, semi-preparative HPLC enantioseparation, establishment of molecular asymmetry and …

P Malik, R Bhushan - New Journal of Chemistry, 2017 - pubs.rsc.org
Herein, enantioseparation of two anti-inflammatory drugs, namely,(RS)-ketorolac and (RS)-
etodolac, commonly marketed and administered as racemates, was achieved by RP-HPLC …

Micellar liquid chromatography for enantioseparation of β-adrenolytics using (S)-ketoprofen-based reagents

S Alwera, R Bhushan - Journal of Liquid Chromatography & …, 2017 - Taylor & Francis
Micellar liquid chromatographic method has been developed for enantioseparation of four β-
adrenolytics, namely,(RS)-salbutamol,(RS)-carvedilol,(RS)-bisoprolol, and (RS)-betaxolol …

Chiral discrimination of mexiletine enantiomers by capillary electrophoresis using cyclodextrins as chiral selectors and experimental design method optimization

M Cârcu-Dobrin, G Hancu, LA Papp, I Fülöp - Molecules, 2022 - mdpi.com
Mexiletine (MXL) is a class IB antiarrhythmic agent, acting as a non-selective voltage-gated
sodium channel blocker, used in therapy as a racemic mixture R, S-MXL hydrochloride. The …

Enantioselective LC analysis and determination of selective serotonin reuptake inhibitors

S Sethi, R Bhushan - Biomedical Chromatography, 2020 - Wiley Online Library
LC separation of biologically and pharmaceutically important enantiomers (from racemic or
non‐racemic mixtures) remains a subject of importance. The present review article deals …