Chlorogenic acid (CGA) is a type of polyphenol compound found in rich concentrations in
many plants such as green coffee beans. As an active natural substance, CGA exerts …

Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

The transmission and processing of pain signals relies critically on the activities of ion
channels that are expressed in afferent pain fibers. This includes voltage-gated channels, as …

Objective: A study was undertaken to describe the clinical spectrum, voltage‐gated
potassium channel (VGKC) complex antibody specificities, and central nervous system …

Chronic pain is associated with abnormal excitability of the somatosensory system and
remains poorly treated in the clinic. Potassium (K+) channels are crucial determinants of …

Neuropathic pain is a refractory disease characterized by maladaptive changes in gene
transcription and translation in the sensory pathway. Long noncoding RNAs (lncRNAs) are …

Potassium channels (KChs) are the most diverse ion channels, in part due to extensive
combinatorial assembly of a large number of principal and auxiliary subunits into an …

Background In the not-too-distant past, the dorsal root ganglion (DRG) was portrayed as a
passive neural structure without involvement in the development or maintenance of chronic …

Nerve injury induces changes in gene transcription in dorsal root ganglion (DRG) neurons,
which may contribute to nerve injury-induced neuropathic pain. DNA methylation represses …

Background The dorsal root ganglion (DRG), in the not too distant past, had been thought of
as a passive organ not involved in the development of abnormal aberrent neuropathic pain …