Origin and functional heterogeneity of fibroblasts
The inherent plasticity and resiliency of fibroblasts make this cell type a conventional tool for
basic research. But where do they come from, are all fibroblasts the same, and how do they …
basic research. But where do they come from, are all fibroblasts the same, and how do they …
Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective
A Huyghe, A Trajkova, F Lavial - Trends in cell biology, 2024 - cell.com
The multistep process of in vivo reprogramming, mediated by the transcription factors (TFs)
Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of …
Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of …
The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening
A mechanistic connection between aging and development is largely unexplored. Through
profiling age-related chromatin and transcriptional changes across 22 murine cell types …
profiling age-related chromatin and transcriptional changes across 22 murine cell types …
Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells
With age, hematopoietic stem cells (HSC) undergo changes in function, including reduced
regenerative potential and loss of quiescence, which is accompanied by a significant …
regenerative potential and loss of quiescence, which is accompanied by a significant …
Fibroblasts as turned agents in cancer progression
R Wieder - Cancers, 2023 - mdpi.com
Simple Summary Normal epithelial cells in our organs are surrounded by stroma, which is
an ecosystem made up of a variety of cells and proteins that support their intended functions …
an ecosystem made up of a variety of cells and proteins that support their intended functions …
DOT1L is a barrier to histone acetylation during reprogramming to pluripotency
Embryonic stem cells (ESCs) have transcriptionally permissive chromatin enriched for gene
activation–associated histone modifications. A striking exception is DOT1L-mediated H3K79 …
activation–associated histone modifications. A striking exception is DOT1L-mediated H3K79 …
Comparative roadmaps of reprogramming and oncogenic transformation identify Bcl11b and Atoh8 as broad regulators of cellular plasticity
Coordinated changes of cellular plasticity and identity are critical for pluripotent
reprogramming and oncogenic transformation. However, the sequences of events that …
reprogramming and oncogenic transformation. However, the sequences of events that …
[HTML][HTML] Transient and permanent reconfiguration of chromatin and transcription factor occupancy drive reprogramming
Somatic cell reprogramming into induced pluripotent stem cells (iPSCs) induces changes in
genome architecture reflective of the embryonic stem cell (ESC) state. However, only a small …
genome architecture reflective of the embryonic stem cell (ESC) state. However, only a small …
Defining human pluripotency
Human pluripotent stem cells harbor the capacity to differentiate into cells from the three
embryonic germ layers, and this ability grants them a central role in modeling human …
embryonic germ layers, and this ability grants them a central role in modeling human …
[HTML][HTML] The transcription factor code in iPSC reprogramming
Transcription factor (TF)-induced reprogramming of somatic cells across lineages and to
induced pluripotent stem cells (iPSCs) has revealed a remarkable plasticity of differentiated …
induced pluripotent stem cells (iPSCs) has revealed a remarkable plasticity of differentiated …