Owing to their morphological complexity and dense network connections, neurons modify
their proteomes locally, using mRNAs and ribosomes present in the neuropil (tissue …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta-CoV that recently
emerged as a human pathogen and is the causative agent of the COVID-19 pandemic. A …

Translation initiation defines the identity and quantity of a synthesized protein. The process
is dysregulated in many human diseases,. A key commitment step is when the ribosomal …

In the past few decades, our view of ribosomes has changed substantially. Rather than
passive machines without significant variability, it is now acknowledged that they are …

Summary Nonstructural protein 1 (Nsp1) produced by coronaviruses inhibits host protein
synthesis. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Nsp1 C …

Regionalisation of molecular mechanisms allows cells to fine-tune their responses to
dynamic environments. In this context, scaffolds are well-known mediators of localised …

Protein UFMylation, ie, post‐translational modification with ubiquitin‐fold modifier 1 (UFM1),
is essential for cellular and endoplasmic reticulum homeostasis. Despite its biological …

Mitochondria are the powerhouse of eukaryotic cells. They possess their own gene
expression machineries where highly divergent and specialized ribosomes, named …

Stalled ribosomes at the endoplasmic reticulum (ER) are covalently modified with the
ubiquitin-like protein UFM1 on the 60S ribosomal subunit protein RPL26 (also known as …

Translation termination, which liberates a nascent polypeptide from the ribosome specifically
at stop codons, must occur accurately and rapidly. We established single-molecule …