Ischemia-reperfusion injury is associated with serious clinical manifestations, including
myocardial hibernation, acute heart failure, cerebral dysfunction, gastrointestinal …

Abstract Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of
programmed cell death discovered and investigated in recent years. There are already …

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal
inflammatory response, RIPK1 is regulated post-translationally by well-characterized …

Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific
tumour types, and in engineered cells overexpressing oncogenic RAS. Yet, its relevance in …

The NF-κB family of inducible transcription factors is activated in response to a variety of
stimuli. Amongst the best-characterized inducers of NF-κB are members of the TNF family of …

In the last decade, the role of apoptosis in the pathophysiology of acute kidney injury (AKI)
and AKI to chronic kidney disease (CKD) progression has been revisited as our …

Inflammation is triggered when innate immune cells detect infection or tissue injury.
Surveillance mechanisms involve pattern recognition receptors (PRRs) on the cell surface …

Tumor necrosis factor (TNF) is a proinflammatory cytokine that coordinates tissue
homeostasis by regulating cytokine production, cell survival, and cell death. However, how …

Abstract Receptor-interacting protein 1 (RIP1) kinase has emerged as a key upstream
regulator that controls inflammatory signalling as well as the activation of multiple cell death …

For a long time, apoptosis was considered the sole form of programmed cell death during
development, homeostasis and disease, whereas necrosis was regarded as an unregulated …