The superoxide radical switch in the biology of nitric oxide and peroxynitrite

L Piacenza, A Zeida, M Trujillo… - Physiological …, 2022 - journals.physiology.org
The free radical nitric oxide (· NO) is a key mediator in different physiological processes such
as vasodilation, neurotransmission, inflammation, and cellular immune responses, and thus …

Neutrophil extracellular traps and organ dysfunction in sepsis

S Kumar, N Payal, VK Srivastava, S Kaushik… - Clinica Chimica …, 2021 - Elsevier
Sepsis is a clinical syndrome resulting from infection followed by inflammation and is one of
the significant causes of mortality worldwide. The underlying reason is the host's …

Free radicals, mitochondrial dysfunction and sepsis-induced organ dysfunction: A mechanistic insight

S Kumar, VK Srivastava, S Kaushik… - Current …, 2024 - benthamdirect.com
Sepsis is a complex clinical condition and a leading cause of death worldwide. During
Sepsis, there is a derailment in the host response to infection, which can progress to severe …

Autophagy-driven neutrophil extracellular traps: The dawn of sepsis

Z Huang, H Zhang, X Fu, L Han, H Zhang… - … -Research and Practice, 2022 - Elsevier
Sepsis is a systemic inflammatory syndrome caused by infection disorders. The core
mechanism of sepsis is immune dysfunction. Neutrophils are the most abundant circulating …

Exploring potential therapeutic agents for lipopolysaccharide-induced septic cardiomyopathy based on transcriptomics using bioinformatics

S Feng, K Cai, S Lin, X Chen, Y Luo, J Wang, G Lian… - Scientific Reports, 2023 - nature.com
Septic cardiomyopathy (SCM) is a common and severe complication of sepsis,
characterized by left ventricular dilation and reduced ejection fraction leading to heart …

[HTML][HTML] Unravelling the Differential Host Immuno-Inflammatory Responses to Staphylococcus aureus and Escherichia coli Infections in Sepsis

E Gupta, S Kumar, VK Srivastava, J Saxena… - Vaccines, 2022 - mdpi.com
Previous reports from our lab have documented dysregulated host inflammatory reactions in
response to bacterial infections in sepsis. Both Gram-negative bacteria (GNB) and Gram …

Transcriptomic profiling revealed immune-related signaling pathways in response to experimental infection of Leishmania donovani in two desert lizards from …

Y **ao, J He, X Guo, X Zheng, Z Zhu, Q Zhou… - Developmental & …, 2024 - Elsevier
Little is known about the immune response of lizards to Leishmania parasties. In this study,
we conducted the first liver transcriptome analysis of two lizards (Phrynocephalus …

Assessment of Sumatriptan on Sepsis-Induced Kidney injury in the Cecal Ligation and Puncture Mice Model

H Yousefi-Manesh, S Shirooie, T Noori… - Drug …, 2022 - thieme-connect.com
Sepsis is a severe systemic inflammatory response with high mortality rate resulting from
different microorganisms. Cytokines activation is essential for the immune response, but in …

Aseptic inflammation as the essential link in the pathogenesis of endometrioid disease

HAM Hromova AM, KOM Ketova OM… - Медичні перспективи …, 2023 - repo.dma.dp.ua
The paper was aimed at determination of the quantitative activity of iNOS and Arg1, as well
as M1 and M2 phenotype macrophages in women with endometrioid disease to establish …

Pro-oxidants

A Khelfi - Biomarkers of Oxidative Stress: Basics and …, 2024 - Springer
Reactive species (RS) are important factors involved in the vast majority of cell disorders.
The generated oxidative damages are underlying factors implicated in many diseases …