The GABAergic deficit hypothesis of major depressive disorder
B Luscher, Q Shen, N Sahir - Molecular psychiatry, 2011 - nature.com
Increasing evidence points to an association between major depressive disorders (MDDs)
and diverse types of GABAergic deficits. In this review, we summarize clinical and preclinical …
and diverse types of GABAergic deficits. In this review, we summarize clinical and preclinical …
Brain mechanisms of HPA axis regulation: neurocircuitry and feedback in context Richard Kvetnansky lecture
Regulation of stress reactivity is a fundamental priority of all organisms. Stress responses
are critical for survival, yet can also cause physical and psychological damage. This review …
are critical for survival, yet can also cause physical and psychological damage. This review …
Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions
The current study, in parallel experiments, evaluated the impact of chronic psychological
stress on physiological and behavioural measures, and on the activation status of microglia …
stress on physiological and behavioural measures, and on the activation status of microglia …
Alcohol, stress, and glucocorticoids: From risk to dependence and relapse in alcohol use disorders
In this review, we detail the clinical evidence supporting the role of psychological and
physiological stress in instrumental motivation for alcohol consumption during the …
physiological stress in instrumental motivation for alcohol consumption during the …
Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part II: physiological and pharmacological …
ER Samuels, E Szabadi - Current neuropharmacology, 2008 - ingentaconnect.com
The locus coeruleus (LC), the major noradrenergic nucleus of the brain, gives rise to fibres
innervating most structures of the neuraxis. Recent advances in neuroscience have helped …
innervating most structures of the neuraxis. Recent advances in neuroscience have helped …
Stress-induced prefrontal reorganization and executive dysfunction in rodents
The prefrontal cortex (PFC) mediates a range of higher order 'executive functions' that
subserve the selection and processing of information in such a way that behavior can be …
subserve the selection and processing of information in such a way that behavior can be …
Neuroanatomical substrates of rodent social behavior: the medial prefrontal cortex and its projection patterns
J Ko - Frontiers in neural circuits, 2017 - frontiersin.org
Social behavior encompasses a number of distinctive and complex constructs that form the
core elements of human imitative culture, mainly represented as either affiliative or …
core elements of human imitative culture, mainly represented as either affiliative or …
Regional differentiation of the medial prefrontal cortex in regulating adaptive responses to acute emotional stress
The medial prefrontal cortex (mPFC) is an important neural substrate for integrating
cognitive-affective information and regulating the hypothalamo–pituitary–adrenal (HPA) axis …
cognitive-affective information and regulating the hypothalamo–pituitary–adrenal (HPA) axis …
Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the hypothalamic-pituitary-adrenal axis
The hypothalamic-pituitary-adrenal (HPA) axis regulates the outflow of glucocorticoid
hormones under basal conditions and in response to stress. Within the last decade, a large …
hormones under basal conditions and in response to stress. Within the last decade, a large …
Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response
The mechanisms subserving the ability of glucocorticoid signaling within the medial
prefrontal cortex (mPFC) to terminate stress-induced activation of the hypothalamic–pituitary …
prefrontal cortex (mPFC) to terminate stress-induced activation of the hypothalamic–pituitary …