The hitchhiker's guide to flow chemistry∥

MB Plutschack, B Pieber, K Gilmore… - Chemical …, 2017 - ACS Publications
Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous
stream rather than in a flask. Flow equipment provides chemists with unique control over …

Taming hazardous chemistry by continuous flow technology

M Movsisyan, EIP Delbeke, J Berton… - Chemical Society …, 2016 - pubs.rsc.org
Over the last two decades, flow technologies have become increasingly popular in the field
of organic chemistry, offering solutions for engineering and/or chemical problems. Flow …

Continuous‐flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients

B Gutmann, D Cantillo… - Angewandte Chemie …, 2015 - Wiley Online Library
In the past few years, continuous‐flow reactors with channel dimensions in the micro‐or
millimeter region have found widespread application in organic synthesis. The characteristic …

Advanced real‐time process analytics for multistep synthesis in continuous flow

P Sagmeister, R Lebl, I Castillo, J Rehrl… - Angewandte Chemie …, 2021 - Wiley Online Library
In multistep continuous flow chemistry, studying complex reaction mixtures in real time is a
significant challenge, but provides an opportunity to enhance reaction understanding and …

Continuous manufacturing in pharmaceutical process development and manufacturing

CL Burcham, AJ Florence… - Annual review of …, 2018 - annualreviews.org
The pharmaceutical industry has found new applications for the use of continuous
processing for the manufacture of new therapies currently in development. The …

Flow fine synthesis with heterogeneous catalysts

K Masuda, T Ichitsuka, N Koumura, K Sato… - Tetrahedron, 2018 - Elsevier
In the past few decades, organic reactions under flow conditions have attracted increasing
attention. Flow reactions have a number of advantages over batch reactions in terms of …

Continuous flow organic chemistry: successes and pitfalls at the interface with current societal challenges

R Gérardy, N Emmanuel, T Toupy… - European Journal of …, 2018 - Wiley Online Library
This review intends to provide the reader with a clear and concise overview of how
preparative continuous flow organic chemistry could potentially impact on current important …

[HTML][HTML] The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

M Baumann, IR Baxendale - Beilstein journal of organic …, 2015 - beilstein-journals.org
The implementation of continuous flow processing as a key enabling technology has
transformed the way we conduct chemistry and has expanded our synthetic capabilities. As …

Kontinuierliche Durchflussverfahren: ein Werkzeug für die sichere Synthese von pharmazeutischen Wirkstoffen

B Gutmann, D Cantillo, CO Kappe - Angewandte Chemie, 2015 - Wiley Online Library
In den letzten Jahren haben Durchflussreaktoren mit Kanalabmessungen im Mikrometer‐
oder Millimeterbereich weitverbreitete Anwendung in der organischen Synthese gefunden …

Fixed bed continuous hydrogenations in trickle flow mode: A pharmaceutical industry perspective

E Masson, EM Maciejewski… - … Process Research & …, 2022 - ACS Publications
Since the 1930s, fixed bed reactors (FBR) have been operated for continuous
hydrogenation reactions in the petrochemical/fine chemical industries, with publications …