Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis

PH Nguyen, A Ramamoorthy, BR Sahoo… - Chemical …, 2021 - ACS Publications
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Food protein aggregation and its application

Z Zhu, AP Bassey, Y Cao, Y Ma, M Huang… - Food research …, 2022 - Elsevier
The phenomenon of protein aggregation in food science is very common, but the formation
mechanism is unclear. The formation of protein aggregates (PAs) is influenced by various …

Changes in structure, rheological property and antioxidant activity of soy protein isolate fibrils by ultrasound pretreatment and EGCG

X Tong, J Cao, T Tian, B Lyu, L Miao, Z Lian, W Cui… - Food …, 2022 - Elsevier
Impacts of ultrasound pretreatment on the formation of soy protein fibrils, interaction of soy
protein fibrils and EGCG, rheological property and antioxidant activity of the complex, and …

Phase separation in biology; functional organization of a higher order

DM Mitrea, RW Kriwacki - Cell Communication and Signaling, 2016 - Springer
Inside eukaryotic cells, macromolecules are partitioned into membrane-bounded
compartments and, within these, some are further organized into non-membrane-bounded …

Mass photometric detection and quantification of nanoscale α-synuclein phase separation

S Ray, TO Mason, L Boyens-Thiele, A Farzadfard… - Nature …, 2023 - nature.com
Protein liquid–liquid phase separation can lead to disease-related amyloid fibril formation.
The mechanisms of conversion of monomeric protein into condensate droplets and of the …

Simulation studies of amyloidogenic polypeptides and their aggregates

IM Ilie, A Caflisch - Chemical reviews, 2019 - ACS Publications
Amyloids, fibrillar assembly of (poly) peptide chains, are associated with neurodegenerative
illnesses such as Alzheimer's and Parkinson's diseases, for which there are no cures. The …

Food-grade Pickering emulsions stabilized by ovotransferrin fibrils

Z Wei, J Cheng, Q Huang - Food Hydrocolloids, 2019 - Elsevier
The present work aimed to explore the feasibility of fabricating stable food-grade Pickering
emulsions stabilized by ovotransferrin (OVT) fibrils. Raman imaging microscopy and …

Role of water in protein aggregation and amyloid polymorphism

D Thirumalai, G Reddy, JE Straub - Accounts of chemical …, 2012 - ACS Publications
A variety of neurodegenerative diseases are associated with amyloid plaques, which begin
as soluble protein oligomers but develop into amyloid fibrils. Our incomplete understanding …

High-resolution probing of early events in amyloid-β aggregation related to Alzheimer's disease

BR Sahoo, SJ Cox, A Ramamoorthy - Chemical Communications, 2020 - pubs.rsc.org
In Alzheimer's disease (AD), soluble oligomers of amyloid-β (Aβ) are emerging as a crucial
entity in driving disease progression as compared to insoluble amyloid deposits. The lacuna …

[HTML][HTML] Significance of native PLGA nanoparticles in the treatment of Alzheimer's disease pathology

B Anand, Q Wu, M Nakhaei-Nejad, G Karthivashan… - Bioactive Materials, 2022 - Elsevier
Alzheimer's disease (AD) is believed to be triggered by increased levels/aggregation of β-
amyloid (Aβ) peptides. At present, there is no effective disease-modifying treatment for AD …