The key role of interleukin-17 (IL-17) and T helper 17 (TH17) cells in tissue inflammation,
autoimmunity and host defence led to the experimental targeting of these molecules in …

IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes,
including host defense, tissue repair, the pathogenesis of inflammatory disease and the …

Fungal diseases represent an important paradigm in immunology, as they can result from
either a lack of recognition by the immune system or overactivation of the inflammatory …

Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger
intracellular signaling cascades that initiate and direct innate and adaptive immune …

The recent discovery of a new CD4+ T cell subset, Th17, has transformed our understanding
of the pathogenetic basis of an increasing number of chronic immune-mediated diseases …

Summary Interleukin-17 (IL-17) and IL-17 receptor (IL-17R) signaling are essential for
regulating mucosal host defense against many invading pathogens. Commensal bacteria …

Commensal fungi of the mammalian skin, such as those of the genus Malassezia, are
associated with atopic dermatitis and other common inflammatory skin disorders …

IL-17–mediated immunity has emerged as a crucial host defense mechanism against fungal
infections. Although Th cells are generally thought to act as the major source of IL-17 in …

Th17 and IL‐17 play important roles in the clearance of extracellular bacterial and fungal
infections. However, strong evidence also implicates the Th17 lineage in several …

The respiratory tree maintains sterilizing immunity against human fungal pathogens.
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …