RNA ac4C modification is a novel and rare chemical modification observed in mRNA.
Traditional biochemical studies had primarily associated ac4C modification with tRNA and …

Chemical modifications of ribonucleotides significantly alter the physicochemical properties
and functions of RNA. Initially perceived as static and essential marks in ribosomal RNA …

Introduction: N4-acetylcytidine (ac4C) is a critical acetylation modification that has an
essential function in protein translation and is associated with a number of human diseases …

We recently reported the distribution of N4-acetylcytidine (ac4C) in HeLa mRNA at base
resolution through chemical reduction and the induction of C: T mismatches in sequencing …

The functional analysis of epitranscriptomic modifications in RNA is constrained by a lack of
methods that accurately capture their locations and levels. We previously demonstrated that …

Abstract N4‐acetylcytidine (ac4C) modification is a crucial RNA modification widely present
in eukaryotic RNA. Previous studies have demonstrated that ac4C plays a pivotal role in …

In recent years, concerted efforts to map and understand epitranscriptomic modifications in
mRNA have unveiled new complexities in the regulation of gene expression. These studies …

Appropriate levels of gene expression are required for cellular fitness and survival.
Messenger RNAs (mRNAs) play a central role in gene expression and thus must be tightly …