Testis development

JA Mäkelä, JJ Koskenniemi, HE Virtanen… - Endocrine …, 2019 - academic.oup.com
Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

Sry and SoxE genes: How they participate in mammalian sex determination and gonadal development?

ZY She, WX Yang - Seminars in Cell & Developmental Biology, 2017 - Elsevier
In mammals, sex determination defines the differentiation of the bipotential genital ridge into
either testes or ovaries. Sry, the mammalian Y-chromosomal testis-determining gene, is a …

Blood-testis barrier and spermatogenesis: lessons from genetically-modified mice

XH Jiang, I Bukhari, W Zheng, S Yin… - Asian journal of …, 2014 - journals.lww.com
The blood-testis barrier (BTB) is found between adjacent Sertoli cells in the testis where it
creates a unique microenvironment for the development and maturation of meiotic and …

Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration

FJ Barrionuevo, A Hurtado, GJ Kim, FM Real, M Bakkali… - Elife, 2016 - elifesciences.org
The new concept of mammalian sex maintenance establishes that particular key genes must
remain active in the differentiated gonads to avoid genetic sex reprogramming, as described …

Comprehensive Analysis of the Transcriptome-Wide m6A Methylome in Shaziling Pig Testicular Development

C Chen, X Tang, S Yan, A Yang, J **ang… - International Journal of …, 2023 - mdpi.com
RNA N 6-methyladenosine (m6A) modification is one of the principal post-transcriptional
modifications and plays a dynamic role in testicular development and spermatogenesis …

Sox8 and Sox10 jointly maintain myelin gene expression in oligodendrocytes

T Turnescu, J Arter, S Reiprich, ER Tamm, A Waisman… - Glia, 2018 - Wiley Online Library
In Schwann cells of the vertebrate peripheral nervous system, induction of myelination and
myelin maintenance both depend on the HMG‐domain‐containing transcription factor …

Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells

S Panneerdoss, S Viswanadhapalli… - Nature …, 2017 - nature.com
Phagocytic clearance of apoptotic germ cells by Sertoli cells is vital for germ cell
development and differentiation. Here, using a tissue-specific miRNA transgenic mouse …

Retracted: Research Article Flavocoxid Protects Against Cadmium-Induced Disruption of the Blood-Testis Barrier and Improves Testicular Damage and Germ Cell …

L Minutoli, A Micali, A Pisani, D Puzzolo… - Toxicological …, 2015 - academic.oup.com
Cadmium (Cd) causes male infertility. There is the need to identify safe treatments
counteracting this toxicity. Flavocoxid is a flavonoid that induces a balanced inhibition of …

Scrotal insulation and sperm production in the boar

JJ Parrish, KL Willenburg, KM Gibbs… - Molecular …, 2017 - Wiley Online Library
Seasonal infertility is a limiting factor in boar fertility, and is increasingly important as climate
changes. Spermatogenesis in the boar produces 256 spermatozoa per type A1 …

Polydeoxyribonucleotide, an Adenosine-A2A Receptor Agonist, Preserves Blood Testis Barrier from Cadmium-Induced Injury

F Squadrito, A Micali, M Rinaldi, N Irrera… - Frontiers in …, 2017 - frontiersin.org
Cadmium (Cd) impairs blood-testis barrier (BTB). Polydeoxyribonucleotide (PDRN), an
adenosine A2A agonist, has positive effects on male reproductive system. We investigated …