Synthetic DNA is of increasing demand across many sectors of research and commercial
activities. Engineering biology, therapy, data storage and nanotechnology are set for rapid …

With the total amount of worldwide data skyrocketing, the global data storage demand is
predicted to grow to 1.75× 1014 GB by 2025. Traditional storage methods have difficulties …

With the explosion of digital world, the dramatically increasing data volume is expected to
reach 175 ZB (1 ZB= 1012 GB) in 2025. Storing such huge global data would consume tons …

Heritable variation in gene expression is common within and between species. This
variation arises from mutations that alter the form or function of molecular gene regulatory …

Forward genetic screens are powerful tools for the discovery and functional annotation of
genetic elements. Recently, the RNA-guided CRISPR (clustered regularly interspaced short …

The chemical synthesis of DNA oligonucleotides and their assembly into synthons, genes,
circuits, and even entire genomes by gene synthesis methods has become an enabling …

DNA is an emerging medium for digital data and its adoption can be accelerated by
synthesis processes specialized for storage applications. Here, we describe a de novo …

Owing to its longevity and enormous information density, DNA, the molecule encoding
biological information, has emerged as a promising archival storage medium. However, due …

The TP53 gene is frequently mutated in human cancer. Research has focused
predominantly on six major" hotspot" codons, which account for only∼ 30% of cancer …

For over 60 years, the synthetic production of new DNA sequences has helped researchers
understand and engineer biology. Here we summarize methods and caveats for the de novo …