Rational design in photopharmacology with molecular photoswitches
Photopharmacology is an attractive approach for achieving targeted drug action with the use
of light. In photopharmacology, molecular photoswitches are introduced into the structure of …
of light. In photopharmacology, molecular photoswitches are introduced into the structure of …
Photoresponsive small molecule Inhibitors for the remote control of enzyme activity
D Laczi, MD Johnstone… - Chemistry–An Asian …, 2022 - Wiley Online Library
The development of new and effective therapeutics is reliant on the ability to study the
underlying mechanisms of potential drug targets in live cells and multicellular systems. A …
underlying mechanisms of potential drug targets in live cells and multicellular systems. A …
Aza‐Diarylethenes Undergoing Both Photochemically and Thermally Reversible Electrocyclic Reactions
S Hamatani, D Kitagawa… - Angewandte Chemie …, 2024 - Wiley Online Library
Exploring novel molecular photoswitches plays a crucial role in the field of photo‐functional
materials chemistry. In this study, we synthesized aza‐diarylethenes with benzothiophene …
materials chemistry. In this study, we synthesized aza‐diarylethenes with benzothiophene …
Control of metalloenzyme activity using photopharmacophores
Metalloenzymes are responsible for numerous physiological and pathological processes in
living organisms; however, there are very few FDA-approved metalloenzyme-targeting …
living organisms; however, there are very few FDA-approved metalloenzyme-targeting …
Hypothesis-Driven, Structure-Based Design in Photopharmacology: The Case of eDHFR Inhibitors
P Kobauri, NS Galenkamp, AM Schulte… - Journal of Medicinal …, 2022 - ACS Publications
Photopharmacology uses light to regulate the biological activity of drugs. This precise
control is obtained through the incorporation of molecular photoswitches into bioactive …
control is obtained through the incorporation of molecular photoswitches into bioactive …
Rational design and development of a lit-active photoswitchable inhibitor targeting CENP-E
K Matsuo, N Tamaoki - Organic & Biomolecular Chemistry, 2021 - pubs.rsc.org
In the emerging field of photopharmacology, synthetic photoswitches based on reversible
photochemical reactions are fused to bioactive molecules. Azobenzene derivatives, which …
photochemical reactions are fused to bioactive molecules. Azobenzene derivatives, which …
Enlightening epigenetics: optochemical tools illuminate the path
K Su, O Vázquez - Trends in Biochemical Sciences, 2024 - cell.com
Optochemical tools have become potent instruments for understanding biological processes
at the molecular level, and the past decade has witnessed their use in epigenetics and …
at the molecular level, and the past decade has witnessed their use in epigenetics and …
Fast E/Z UV-light response T-type photoswitching of phenylene-thienyl imines
New types of imine switches containing an alkylated para-bis (2-thienyl) phenylene moiety
have been synthesized and studied. A bis substituted 2, 4-diiminotoluene with phenylene …
have been synthesized and studied. A bis substituted 2, 4-diiminotoluene with phenylene …
Photoswitchable Cytotoxins
O Thorn‐Seshold - … , Properties, and Applications, 2 Volume Set, 2022 - Wiley Online Library
Photoswitchable cytotoxins (PSCs) have high value as spatiotemporally precise research
reagents to modulate critical biological processes. Compared to other …
reagents to modulate critical biological processes. Compared to other …
Rational drug design in photopharmacology
P Kobauri - 2022 - research.rug.nl
Photopharmacology uses light to regulate the biological activity of drugs. This precise
control is obtained through the incorporation of molecular photoswitches into bioactive …
control is obtained through the incorporation of molecular photoswitches into bioactive …