Myelin is the lipid-rich structure formed by oligodendrocytes (OLs) that wraps the axons in
multilayered sheaths, assuring protection, efficient saltatory signal conduction and metabolic …

Idiopathic Parkinson's disease is characterized by a progressive loss of dopaminergic
neurons, but the exact disease aetiology remains largely unknown. To date, Parkinson's …

Oligodendrocyte progenitor cells (OPCs) are the most proliferative and dispersed population
of progenitor cells in the adult central nervous system, which allows these cells to rapidly …

Ambient RNA contamination in single-cell and single-nuclei RNA sequencing (snRNA-seq)
is a significant problem, but its consequences are poorly understood. Here, we show that …

Neurogenesis processes differ in different areas of the cortex in many species, including
humans. Here, we performed single-cell transcriptome profiling of the four cortical lobes and …

The heterogeneity and molecular characteristics of progenitor cells, especially glial
progenitors, in the develo** human cerebral cortex remain elusive. Here, we find that …

Injury and loss of oligodendrocytes can cause demyelinating diseases such as multiple
sclerosis. To improve our understanding of human oligodendrocyte development, which …

Multiple sclerosis (MS) is a chronic, autoimmune and neuroinflammatory disease of the
central nervous system (CNS) mediated by autoreactive T cells directed against myelin …

The hypothalamus comprises various nuclei and neuronal subpopulations that control
fundamental homeostasis and behaviors. However, spatiotemporal molecular …

In the central nervous system, oligodendrocytes (OLs) produce myelin sheaths that provide
trophic support to neuronal axons and increase the propagation speed of action potential …