Mechanisms of BCL-2 family proteins in mitochondrial apoptosis
The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …
either promoters or inhibitors of cell death. The functional interplay and balance between the …
Mitochondria in health, disease, and aging
JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research
X Tong, R Tang, M **ao, J Xu, W Wang… - Journal of hematology & …, 2022 - Springer
Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …
body against pathogenic substances. This process, called regulated cell death (RCD), is …
Apoptotic cell death in disease—Current understanding of the NCCD 2023
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
The therapeutic potential of targeting regulated non-apoptotic cell death
Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …
Mitochondrial control of inflammation
Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …
associated molecular patterns (DAMPs) and promote inflammation when released into the …
Targeting ferroptosis as a vulnerability in cancer
Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
W Gao, X Wang, Y Zhou, X Wang, Y Yu - Signal transduction and …, 2022 - nature.com
In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …
Disulfidptosis: disulfide stress–induced cell death
X Liu, L Zhuang, B Gan - Trends in cell biology, 2024 - cell.com
The cystine transporter solute carrier family 7 member 11 (SLC7A11)(also known as xCT)
promotes glutathione synthesis and counters oxidative stress–induced cell death, including …
promotes glutathione synthesis and counters oxidative stress–induced cell death, including …
Immunogenic cell stress and death
Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …
immunological correlates of cellular stress and death. In the absence of reactive antigenic …