Biosynthesis of nicotinamide mononucleotide: Current metabolic engineering strategies, challenges, and prospects

S Luo, J Zhao, Y Zheng, T Chen, Z Wang - Fermentation, 2023 - mdpi.com
Nicotinamide mononucleotide (NMN) is an essential precursor of nicotinamide adenine
dinucleotide (NAD+), which is widely applied in the pharmaceutical and biotech industries …

Diversity of membrane transport proteins for vitamins in bacteria and archaea

M Jaehme, DJ Slotboom - Biochimica et Biophysica Acta (BBA)-General …, 2015 - Elsevier
Background All organisms use cofactors to extend the catalytic capacities of proteins. Many
bacteria and archaea can synthesize cofactors from primary metabolites, but there are also …

Nitrogen recycling and nutritional provisioning by Blattabacterium, the cockroach endosymbiont

ZL Sabree, S Kambhampati, NA Moran - Proceedings of the National …, 2009 - pnas.org
Nitrogen acquisition and assimilation is a primary concern of insects feeding on diets largely
composed of plant material. Reclaiming nitrogen from waste products provides a rich …

Engineering a nicotinamide mononucleotide redox cofactor system for biocatalysis

WB Black, L Zhang, WS Mak, S Maxel, Y Cui… - Nature chemical …, 2020 - nature.com
Biological production of chemicals often requires the use of cellular cofactors, such as
nicotinamide adenine dinucleotide phosphate (NADP+). These cofactors are expensive to …

Metabolic design for selective production of nicotinamide mononucleotide from glucose and nicotinamide

S Shoji, T Yamaji, H Makino, J Ishii, A Kondo - Metabolic Engineering, 2021 - Elsevier
Abstract β-Nicotinamide mononucleotide (NMN) is, one of the nucleotide compounds, a
precursor of NAD+ and has recently attracted attention as a nutraceutical. Here, we develop …

Exploring the De Novo NMN Biosynthesis as an Alternative Pathway to Enhance NMN Production

P Wang, Y Ma, J Li, J Su, J Chi, X Zhu, X Zhu… - ACS Synthetic …, 2024 - ACS Publications
Nicotinamide mononucleotide (NMN) serves as a precursor for NAD+ synthesis and has
been shown to have positive effects on the human body. Previous research has …

Metabolic engineering of Escherichia coli for optimized biosynthesis of nicotinamide mononucleotide, a noncanonical redox cofactor

WB Black, D Aspacio, D Bever, E King, L Zhang… - Microbial cell …, 2020 - Springer
Background Noncanonical redox cofactors are emerging as important tools in cell-free
biosynthesis to increase the economic viability, to enable exquisite control, and to expand …

Evidence that feedback inhibition of NAD kinase controls responses to oxidative stress

JH Grose, L Joss, SF Velick, JR Roth - Proceedings of the National …, 2006 - pnas.org
Formation of NADP+ from NAD+ is catalyzed by NAD kinase (NadK; EC 2.7. 1.23). Evidence
is presented that NadK is the only NAD kinase of Salmonella enterica and is essential for …

Biosynthesis of β-nicotinamide mononucleotide from glucose via a new pathway in Bacillus subtilis

Z Tan, Y Yang, Y Wu, J Yan, B Zhang, Y Hou… - Frontiers in …, 2024 - frontiersin.org
Introduction β-nicotinamide mononucleotide (β-NMN) is an essential precursor of
nicotinamide adenine dinucleotide (NAD+) and plays a key role in supplying NAD+ and …

Functional mining of transporters using synthetic selections

HJ Genee, AP Bali, SD Petersen, S Siedler… - Nature chemical …, 2016 - nature.com
Only 25% of bacterial membrane transporters have functional annotation owing to the
difficulty of experimental study and of accurate prediction of their function. Here we report a …