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Biosynthesis of nicotinamide mononucleotide: Current metabolic engineering strategies, challenges, and prospects
S Luo, J Zhao, Y Zheng, T Chen, Z Wang - Fermentation, 2023 - mdpi.com
Nicotinamide mononucleotide (NMN) is an essential precursor of nicotinamide adenine
dinucleotide (NAD+), which is widely applied in the pharmaceutical and biotech industries …
dinucleotide (NAD+), which is widely applied in the pharmaceutical and biotech industries …
Diversity of membrane transport proteins for vitamins in bacteria and archaea
M Jaehme, DJ Slotboom - Biochimica et Biophysica Acta (BBA)-General …, 2015 - Elsevier
Background All organisms use cofactors to extend the catalytic capacities of proteins. Many
bacteria and archaea can synthesize cofactors from primary metabolites, but there are also …
bacteria and archaea can synthesize cofactors from primary metabolites, but there are also …
Nitrogen recycling and nutritional provisioning by Blattabacterium, the cockroach endosymbiont
Nitrogen acquisition and assimilation is a primary concern of insects feeding on diets largely
composed of plant material. Reclaiming nitrogen from waste products provides a rich …
composed of plant material. Reclaiming nitrogen from waste products provides a rich …
Engineering a nicotinamide mononucleotide redox cofactor system for biocatalysis
Biological production of chemicals often requires the use of cellular cofactors, such as
nicotinamide adenine dinucleotide phosphate (NADP+). These cofactors are expensive to …
nicotinamide adenine dinucleotide phosphate (NADP+). These cofactors are expensive to …
Metabolic design for selective production of nicotinamide mononucleotide from glucose and nicotinamide
Abstract β-Nicotinamide mononucleotide (NMN) is, one of the nucleotide compounds, a
precursor of NAD+ and has recently attracted attention as a nutraceutical. Here, we develop …
precursor of NAD+ and has recently attracted attention as a nutraceutical. Here, we develop …
Exploring the De Novo NMN Biosynthesis as an Alternative Pathway to Enhance NMN Production
P Wang, Y Ma, J Li, J Su, J Chi, X Zhu, X Zhu… - ACS Synthetic …, 2024 - ACS Publications
Nicotinamide mononucleotide (NMN) serves as a precursor for NAD+ synthesis and has
been shown to have positive effects on the human body. Previous research has …
been shown to have positive effects on the human body. Previous research has …
Metabolic engineering of Escherichia coli for optimized biosynthesis of nicotinamide mononucleotide, a noncanonical redox cofactor
Background Noncanonical redox cofactors are emerging as important tools in cell-free
biosynthesis to increase the economic viability, to enable exquisite control, and to expand …
biosynthesis to increase the economic viability, to enable exquisite control, and to expand …
Evidence that feedback inhibition of NAD kinase controls responses to oxidative stress
Formation of NADP+ from NAD+ is catalyzed by NAD kinase (NadK; EC 2.7. 1.23). Evidence
is presented that NadK is the only NAD kinase of Salmonella enterica and is essential for …
is presented that NadK is the only NAD kinase of Salmonella enterica and is essential for …
Biosynthesis of β-nicotinamide mononucleotide from glucose via a new pathway in Bacillus subtilis
Z Tan, Y Yang, Y Wu, J Yan, B Zhang, Y Hou… - Frontiers in …, 2024 - frontiersin.org
Introduction β-nicotinamide mononucleotide (β-NMN) is an essential precursor of
nicotinamide adenine dinucleotide (NAD+) and plays a key role in supplying NAD+ and …
nicotinamide adenine dinucleotide (NAD+) and plays a key role in supplying NAD+ and …
Functional mining of transporters using synthetic selections
Only 25% of bacterial membrane transporters have functional annotation owing to the
difficulty of experimental study and of accurate prediction of their function. Here we report a …
difficulty of experimental study and of accurate prediction of their function. Here we report a …