Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials

M Dambrova, M Makrecka-Kuka, J Kuka… - Pharmacological …, 2022 - Elsevier
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …

Pharmacological treatment of painful HIV-associated sensory neuropathy: a systematic review and meta-analysis of randomised controlled trials

TJC Phillips, CL Cherry, S Cox, SJ Marshall, ASC Rice - PloS one, 2010 - journals.plos.org
Background Significant pain from HIV-associated sensory neuropathy (HIV-SN) affects∼
40% of HIV infected individuals treated with antiretroviral therapy (ART). The prevalence of …

Carnitine derivatives: clinical usefulness

M Malaguarnera - Current opinion in gastroenterology, 2012 - journals.lww.com
Carnitine derivatives: clinical usefulness : Current Opinion in Gastroenterology Carnitine
derivatives: clinical usefulness : Current Opinion in Gastroenterology Log in or Register …

Acetyl-L-carnitine in painful peripheral neuropathy: a systematic review

G Di Stefano, A Di Lionardo, E Galosi… - Journal of pain …, 2019 - Taylor & Francis
Abstract Acetyl-L-carnitine (ALC) has shown a neuroprotective effect in patients with
peripheral neuropathies of different etiologies. Preclinical studies demonstrated a central …

Acetyl-L-carnitine: from a biological curiosity to a drug for the peripheral nervous system and beyond

M Onofrj, F Ciccocioppo, S Varanese… - Expert review of …, 2013 - Taylor & Francis
Acetyl-l-carnitine (ALC) is a molecule derived from acetylation of carnitine in the
mitochondria. Carnitine acetylation enables the function of CoA and facilitates elimination of …

Effects of acetyl‐L‐carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double‐blind, controlled trial

S Li, X Chen, Q Li, J Du, Z Liu, Y Peng… - Journal of diabetes …, 2016 - Wiley Online Library
Abstract Aims/Introduction To assess the efficacy and safety of acetyl‐L‐carnitine (ALC) on
diabetic peripheral neuropathy compared with methylcobalamin (MC). Materials and …

In vitro assessment of antiretroviral drugs demonstrates potential for ototoxicity

P Thein, GM Kalinec, C Park, F Kalinec - Hearing research, 2014 - Elsevier
Several studies have reported an increased incidence of auditory dysfunction among
HIV/AIDS patients. We used auditory HEI-OC1 cells in cell viability, flow cytometry and …

Potential therapeutic role of carnitine and acetylcarnitine in neurological disorders

C Maldonado, M Vázquez… - Current Pharmaceutical …, 2020 - ingentaconnect.com
Background: Current therapy of neurological disorders has several limitations. Although a
high number of drugs are clinically available, several subjects do not achieve full …

Mitochondrial toxicity in HAART: an overview of in vitro evidence

N Apostolova, A Blas-Garcia… - Current pharmaceutical …, 2011 - ingentaconnect.com
The combined antiretroviral therapeutic approach currently employed for the treatment of
HIV infection, known as Highly Active Antiretroviral Therapy (HAART), has dramatically …

Centenarians and supercentenarians: a black swan. Emerging social, medical and surgical problems

M Vacante, V D'Agata, M Motta, G Malaguarnera… - BMC surgery, 2012 - Springer
Abstract The Black Swan Theory was described by Nassim Nicholas Taleb in his book “The
Black Swan”. This theory refers to “high-impact, hard-to-predict, and rare events beyond the …