Due to the heterogeneous nature of the disease, it is a challenge to capture disease activity
of multiple sclerosis (MS) in a reliable and valid way. Therefore, it can be difficult to assess …

Background A systematic literature review was conducted to (a) identify the most frequently
used health-related quality of life (HRQOL) models and (b) critique those models. Methods …

Книга посвящена вопросам использования опросников, тестов и шкал для оценки
состояния неврологических больных и определения эффективности лечения …

Cognitive impairment is common in multiple sclerosis (MS), yet patients seen in MS clinics
and neurologic practices are not routinely assessed neuropsychologically. In part, poor …

Health-related quality of life (HRQoL) has been more intensively studied in multiple sclerosis
(MS) than in any other neurological disorder. Traditional medical models of impairment and …

Visual impairment is a key manifestation of multiple sclerosis. Acute optic neuritis is a
common, often presenting manifestation, but visual deficits and structural loss of retinal …

Purpose: There is increasing recognition that the global wellbeing of patients with chronic
neurological disease is an important outcome in research and clinical practice alike. Many …

Patient-reported outcomes (PROs) are increasingly used in multiple sclerosis (MS) research
and clinical practice for understanding the effects that the disease and its treatments have on …

Objective: To evaluate the efficacy and safety of interferon beta-1b (IFNβ-1b) in subjects with
secondary progressive multiple sclerosis (SPMS). Methods: This 3-year, multicenter, double …

Many of the available disability outcome measures used in clinical trials of multiple sclerosis
are insensitive to change over time, inadequately validated, or insensitive to patient …