Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …

lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids,
particularly omega-6 and-3 fatty acids, to generate a number of bioactive lipid metabolites. A …

Nonsteroidal anti-inflammatory drugs interfere with the metabolism of arachidonic acid to
proinflammatory prostaglandins and leukotrienes by targeting cyclooxygenases (COXs), 5 …

Acute central nervous system (CNS) trauma, including spinal cord injury (SCI) and traumatic
brain injury (TBI), always leads to severe sensory, motor and autonomic nervous system …

Abstract The endocannabinoids 2-arachidonoyl-glycerol (2-AG) and N-arachidonoyl-
ethanolamine (AEA) are eicosanoids implicated in numerous physiological processes like …

Background Aspirin-exacerbated respiratory disease (AERD) is a mechanistically distinct
subtype of chronic rhinosinusitis with nasal polyps (CRSwNP). Although frequently …

Improving the microenvironment of lesioned spinal cord to minimize the secondary injury is
one important strategy to treat spinal cord injury (SCI). The ensuing hemorrhage after SCI …

The two oxylipins 7S, 14S-dihydroxydocosahexaenoic acid (diHDHA) and 7S, 17S-diHDHA
[resolvin D5 (RvD5)] have been found in macrophages and infectious inflammatory …

A new series of thieno [2, 3-d] pyrimidine derivatives 4, 5, 6a-o, and 11 was designed and
synthesized starting from cyclohexanone under Gewald condition with the aim to develop …

Neutrophils are key players in inflammation initiation and resolution. Little attention has
been paid to the detailed biosynthesis of specialized pro-resolving mediators (SPM) in these …