Adverse drug reactions (ADRs) are an important and frequent cause of morbidity and
mortality. ADR can be related to a variety of drugs, including anticonvulsants, anaesthetics …

Ion channels have recently been recognized as novel therapeutic targets in cancer research
since they are overexpressed in different histological tissues, and their activity is linked to …

Background: The rapid delayed rectifier potassium current (IKr) is important for cardiac
repolarization and is most often involved in drug-induced arrhythmias. However, accurately …

The ERG1 potassium channel, encoded by KCNH2, has long been associated with cardiac
electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology …

Mitochondrial toxicity induced by therapeutic drugs is a major contributor for cardiotoxicity,
posing a serious threat to pharmaceutical industries and patients' lives. However …

Cardiac hERG channels comprise at least two subunits, hERG 1a and hERG 1b, and drive
cardiac action potential repolarization. hERG 1a subunits contain a cytoplasmic PAS domain …

Head and neck cancers are a highly complex and heterogeneous group of malignancies
that involve very diverse anatomical structures and distinct aetiological factors, treatments …

Zebrafish provide a translational model of human cardiac function. Their similar cardiac
electrophysiology enables screening of human cardiac repolarization disorders, drug …

A myriad of cellular responses is dependent on selective membrane-permeation of charged
species through membrane proteins known as ion channels. Among them, the ryanodine …