Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
Deciphering lipid dysregulation in ALS: from mechanisms to translational medicine
Lipids, defined by low solubility in water and high solubility in nonpolar solvents, can be
classified into fatty acids, glycerolipids, glycerophospholipids, sphingolipids, and sterols …
classified into fatty acids, glycerolipids, glycerophospholipids, sphingolipids, and sterols …
A proposed framework to evaluate the quality and reliability of targeted metabolomics assays from the UK Consortium on Metabolic Phenoty** (MAP/UK)
Targeted metabolite assays that measure tens or hundreds of pre-selected metabolites,
typically using liquid chromatography–mass spectrometry, are increasingly being developed …
typically using liquid chromatography–mass spectrometry, are increasingly being developed …
Sphingolipids in neurodegenerative diseases
Neurodegenerative Diseases (NDDs) are a group of disorders that cause progressive
deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is …
deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is …
Advances in proteomic and metabolomic profiling of neurodegenerative diseases
Proteomics and metabolomics are two emerging fields that hold promise to shine light on the
molecular mechanisms causing neurodegenerative diseases. Research in this area may …
molecular mechanisms causing neurodegenerative diseases. Research in this area may …
Fatty acids derived from the probiotic Lacticaseibacillus rhamnosus HA-114 suppress age-dependent neurodegeneration
A Labarre, E Guitard, G Tossing, A Forest… - Communications …, 2022 - nature.com
The human microbiota is believed to influence health. Microbiome dysbiosis may be linked
to neurological conditions like Alzheimer's disease, amyotrophic lateral sclerosis, and …
to neurological conditions like Alzheimer's disease, amyotrophic lateral sclerosis, and …
Metabolomics identifies shared lipid pathways in independent amyotrophic lateral sclerosis cohorts
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease lacking effective
treatments. This is due, in part, to a complex and incompletely understood pathophysiology …
treatments. This is due, in part, to a complex and incompletely understood pathophysiology …
Gut microbiome correlates with plasma lipids in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a complex, fatal neurodegenerative disease. Disease
pathophysiology is incompletely understood but evidence suggests gut dysbiosis occurs in …
pathophysiology is incompletely understood but evidence suggests gut dysbiosis occurs in …
Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD+ balance as a therapeutic strategy
Mitochondrial defects result in dysregulation of metabolomics and energy homeostasis that
are detected in upper motor neurons (UMNs) with TDP-43 pathology, a pathology that is …
are detected in upper motor neurons (UMNs) with TDP-43 pathology, a pathology that is …
Evidence of metabolic dysfunction in amyotrophic lateral sclerosis (ALS) patients and animal models
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor
neurons, leading to muscle weakness, paralysis, and eventual death. Research from the …
neurons, leading to muscle weakness, paralysis, and eventual death. Research from the …