Burden of liver disease in Europe: epidemiology and analysis of risk factors to identify prevention policies
The burden of liver disease in Europe continues to grow. We aimed to describe the
epidemiology of liver diseases and their risk factors in European countries, identifying public …
epidemiology of liver diseases and their risk factors in European countries, identifying public …
HLA variation and disease
Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …
HLA molecules have proven to be central to physiology, protective immunity and …
Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine
Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was
introduced in the United Kingdom to accelerate population coverage with a single dose. At …
introduced in the United Kingdom to accelerate population coverage with a single dose. At …
[PDF][PDF] Changes in the global burden of chronic liver diseases from 2012 to 2017: the growing impact of NAFLD
Background and Aims Chronic hepatitis B virus (HBV), hepatitis C virus (HCV), nonalcoholic
fatty liver disease (NAFLD), and alcohol‐associated liver disease (ALD) are main causes of …
fatty liver disease (NAFLD), and alcohol‐associated liver disease (ALD) are main causes of …
From hepatitis A to E: A critical review of viral hepatitis
Viral infections affecting the liver have had an important impact on humanity, as they have
led to significant morbidity and mortality in patients with acute and chronic infections. Once …
led to significant morbidity and mortality in patients with acute and chronic infections. Once …
[HTML][HTML] Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non …
PM Folegatti, M Bittaye, A Flaxman… - The Lancet Infectious …, 2020 - thelancet.com
Summary Background Cases of Middle East respiratory syndrome coronavirus (MERS-CoV)
infection continue to rise in the Arabian Peninsula 7 years after it was first described in Saudi …
infection continue to rise in the Arabian Peninsula 7 years after it was first described in Saudi …
Getting to HBV cure: The promising paths forward
Chronic HBV infection is a global public health burden estimated to impact nearly 300
million persons worldwide. Despite the advent of potent antiviral agents that effectively …
million persons worldwide. Despite the advent of potent antiviral agents that effectively …
[HTML][HTML] Approaches, progress, and challenges to hepatitis C vaccine development
Risk factors for hepatitis C virus (HCV) infection vary, and there were an estimated 1.75
million new cases worldwide in 2015. The World Health Organization aims for a 90 …
million new cases worldwide in 2015. The World Health Organization aims for a 90 …
Adenoviral-based vaccine promotes neoantigen-specific CD8+ T cell stemness and tumor rejection
Upon chronic antigen exposure, CD8+ T cells become exhausted, acquiring a dysfunctional
state correlated with the inability to control infection or tumor progression. In contrast, stem …
state correlated with the inability to control infection or tumor progression. In contrast, stem …
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells
Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit
immunity to chronic viral infection. Defining novel markers of exhaustion is important both for …
immunity to chronic viral infection. Defining novel markers of exhaustion is important both for …