In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM,
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …

One way to preserve a rare book is to lock it away from all potential sources of damage. Of
course, an inaccessible book is also of little use, and the paper and ink will continue to …

Fanconi anemia (FA) is a complex genetic disorder characterized by bone marrow failure
(BMF), congenital defects, inability to repair DNA interstrand cross-links (ICLs), and cancer …

The Fanconi anaemia pathway repairs DNA interstrand crosslinks (ICLs) in the genome. Our
understanding of this complex pathway is still evolving, as new components continue to be …

Faithful DNA replication is critical for the maintenance of genomic integrity. Although DNA
replication machinery is highly accurate, the process of DNA replication is constantly …

The chemical treatment of cancer started with the realization that DNA damaging agents
such as mustard gas present notable antitumoural properties. Consequently, early drug …

From bacteria to mammalian cells, damaged DNA is sensed and targeted by DNA repair
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …

Complete and accurate DNA replication is fundamental to cellular proliferation and genome
stability. Obstacles that delay, prevent, or terminate DNA replication cause the phenomena …

The interplay between replication stress and the S phase checkpoint is a key determinant of
genome maintenance, and has a major impact on human diseases, notably, tumour …

Transcription and replication both require large macromolecular complexes to act on a DNA
template, yet these machineries cannot simultaneously act on the same DNA sequence …